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Immunogenicity Monitoring System Incorporating Microfluidic Cell Chip and Paper-based Analytical Device
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Publication Year
2023-01-01
Journal
2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
Publisher
Institute of Electrical and Electronics Engineers Inc.
Citation
2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023, pp.2066-2069
Keyword
Cell Metabolite TransducerColorimetric SensingImmunogenicity MonitoringPaper-Based Analytical Device
All Science Classification Codes (ASJC)
Computer Science ApplicationsElectrical and Electronic EngineeringControl and OptimizationInstrumentation
Abstract
With the development of microfluidic chips, there are increasing attempts to integrate cell culture and biomaterial test functions into one chip to supplement experimental animal models [1]. In this study, we developed a simple and easy-to-handle immunogenicity-testing cell chip to evaluate the immunogenicity of biomaterials. On this chip, macrophages were introduced as immunogenicity indicators, and a micro-paper-based analytical device (PAD) was used for optical transducer. In the cell chamber of the developed cell chip, macrophages grow and react to foreign biomaterials. Immune-activated macrophages secrete hydrogen peroxide, which is then transferred to the PAD with single-finger actuation. The hydrogen peroxide molecules reaching the PAD detection zone react with the colorimetric detection substrate, resulting in a color that corresponds to the hydrogen peroxide concentration. With the developed testing chip, the immunogenicity of biomaterials can be determined before administration.
Language
eng
URI
https://aurora.ajou.ac.kr/handle/2018.oak/37012
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85193535961&origin=inward
DOI
https://doi.org/2-s2.0-85193535961
Journal URL
http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=10516699
Type
Conference
Funding
This work was supported by the Creative Materials Discovery Program (NRF-2019M3D1A1078943) and the Priority Research Centers Program (NRF-2019R1A6A1A11051471) funded by the National Research Foundation of Korea. HCY also acknowledges the support from the Technology Innovation Program (10051409) funded by the Ministry of Trade, Industry and Energy (MOTIE, Korea).
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