Citation Export
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kyung Won | - |
dc.contributor.author | Kyeong Yang, Eun | - |
dc.contributor.author | Yoon, Hyun Chul | - |
dc.date.issued | 2023-01-01 | - |
dc.identifier.uri | https://aurora.ajou.ac.kr/handle/2018.oak/37012 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85193535961&origin=inward | - |
dc.description.abstract | With the development of microfluidic chips, there are increasing attempts to integrate cell culture and biomaterial test functions into one chip to supplement experimental animal models [1]. In this study, we developed a simple and easy-to-handle immunogenicity-testing cell chip to evaluate the immunogenicity of biomaterials. On this chip, macrophages were introduced as immunogenicity indicators, and a micro-paper-based analytical device (PAD) was used for optical transducer. In the cell chamber of the developed cell chip, macrophages grow and react to foreign biomaterials. Immune-activated macrophages secrete hydrogen peroxide, which is then transferred to the PAD with single-finger actuation. The hydrogen peroxide molecules reaching the PAD detection zone react with the colorimetric detection substrate, resulting in a color that corresponds to the hydrogen peroxide concentration. With the developed testing chip, the immunogenicity of biomaterials can be determined before administration. | - |
dc.description.sponsorship | This work was supported by the Creative Materials Discovery Program (NRF-2019M3D1A1078943) and the Priority Research Centers Program (NRF-2019R1A6A1A11051471) funded by the National Research Foundation of Korea. HCY also acknowledges the support from the Technology Innovation Program (10051409) funded by the Ministry of Trade, Industry and Energy (MOTIE, Korea). | - |
dc.language.iso | eng | - |
dc.publisher | Institute of Electrical and Electronics Engineers Inc. | - |
dc.title | Immunogenicity Monitoring System Incorporating Microfluidic Cell Chip and Paper-based Analytical Device | - |
dc.type | Conference | - |
dc.citation.conferenceDate | 2023.6.25. ~ 2023.6.29. | - |
dc.citation.conferenceName | 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 | - |
dc.citation.edition | 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 | - |
dc.citation.endPage | 2069 | - |
dc.citation.startPage | 2066 | - |
dc.citation.title | 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 | - |
dc.identifier.bibliographicCitation | 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023, pp.2066-2069 | - |
dc.identifier.doi | 2-s2.0-85193535961 | - |
dc.identifier.scopusid | 2-s2.0-85193535961 | - |
dc.identifier.url | http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=10516699 | - |
dc.subject.keyword | Cell Metabolite Transducer | - |
dc.subject.keyword | Colorimetric Sensing | - |
dc.subject.keyword | Immunogenicity Monitoring | - |
dc.subject.keyword | Paper-Based Analytical Device | - |
dc.type.other | Conference Paper | - |
dc.subject.subarea | Computer Science Applications | - |
dc.subject.subarea | Electrical and Electronic Engineering | - |
dc.subject.subarea | Control and Optimization | - |
dc.subject.subarea | Instrumentation | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.