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Immunogenicity Monitoring System Incorporating Microfluidic Cell Chip and Paper-based Analytical Device
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dc.contributor.authorLee, Kyung Won-
dc.contributor.authorKyeong Yang, Eun-
dc.contributor.authorYoon, Hyun Chul-
dc.date.issued2023-01-01-
dc.identifier.urihttps://aurora.ajou.ac.kr/handle/2018.oak/37012-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85193535961&origin=inward-
dc.description.abstractWith the development of microfluidic chips, there are increasing attempts to integrate cell culture and biomaterial test functions into one chip to supplement experimental animal models [1]. In this study, we developed a simple and easy-to-handle immunogenicity-testing cell chip to evaluate the immunogenicity of biomaterials. On this chip, macrophages were introduced as immunogenicity indicators, and a micro-paper-based analytical device (PAD) was used for optical transducer. In the cell chamber of the developed cell chip, macrophages grow and react to foreign biomaterials. Immune-activated macrophages secrete hydrogen peroxide, which is then transferred to the PAD with single-finger actuation. The hydrogen peroxide molecules reaching the PAD detection zone react with the colorimetric detection substrate, resulting in a color that corresponds to the hydrogen peroxide concentration. With the developed testing chip, the immunogenicity of biomaterials can be determined before administration.-
dc.description.sponsorshipThis work was supported by the Creative Materials Discovery Program (NRF-2019M3D1A1078943) and the Priority Research Centers Program (NRF-2019R1A6A1A11051471) funded by the National Research Foundation of Korea. HCY also acknowledges the support from the Technology Innovation Program (10051409) funded by the Ministry of Trade, Industry and Energy (MOTIE, Korea).-
dc.language.isoeng-
dc.publisherInstitute of Electrical and Electronics Engineers Inc.-
dc.titleImmunogenicity Monitoring System Incorporating Microfluidic Cell Chip and Paper-based Analytical Device-
dc.typeConference-
dc.citation.conferenceDate2023.6.25. ~ 2023.6.29.-
dc.citation.conferenceName22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023-
dc.citation.edition2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023-
dc.citation.endPage2069-
dc.citation.startPage2066-
dc.citation.title2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023-
dc.identifier.bibliographicCitation2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023, pp.2066-2069-
dc.identifier.doi2-s2.0-85193535961-
dc.identifier.scopusid2-s2.0-85193535961-
dc.identifier.urlhttp://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=10516699-
dc.subject.keywordCell Metabolite Transducer-
dc.subject.keywordColorimetric Sensing-
dc.subject.keywordImmunogenicity Monitoring-
dc.subject.keywordPaper-Based Analytical Device-
dc.type.otherConference Paper-
dc.subject.subareaComputer Science Applications-
dc.subject.subareaElectrical and Electronic Engineering-
dc.subject.subareaControl and Optimization-
dc.subject.subareaInstrumentation-
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