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Quantitative Cell Migration Monitoring Method Using Retroreflective Janus Particles
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Publication Year
2023-01-01
Journal
2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
Publisher
Institute of Electrical and Electronics Engineers Inc.
Citation
2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023, pp.979-982
Keyword
Arg-Gly-Asp (RGD) peptidecell adhesive patternCell migrationQuantificationRetroreflective Janus particles (RJP)
All Science Classification Codes (ASJC)
Computer Science ApplicationsElectrical and Electronic EngineeringControl and OptimizationInstrumentation
Abstract
Conventional migration assays are widely used for drug screening, but non-standardized experimental conditions compromise the reliability of the assay. Therefore, we developed a standardized quantitative cell migration assay using retroreflective Janus particles (RJP). In this study, RJP and cell adhesive patterns were used as a signaling probe and a sensing surface. On the patterned surface, retroreflective signals are represented as bright dots using white LED. By counting the number of RJP, we could simply quantify cell mobility. To verify the availability of the developed method, the mobility of cyclic Arg-Gly-Asp (RGD) peptide-treated L929 fibroblast was successfully quantified as a model case.
Language
eng
URI
https://aurora.ajou.ac.kr/handle/2018.oak/36910
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85193463530&origin=inward
Journal URL
http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=10516699
Type
Conference
Funding
This work was supported by the Creative Materials Discovery Program (NRF-2019M3D1A1078943) and research grants (NRF-2019R1A6A1A11051471, NRF-2021R1A2C3004180) funded by the National Research Foundation of Korea. H.C.Y also acknowledges the support from the Commercialization Promotion Agency for R&D Outcomes grant funded by the Korea government (2021N100).
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Yoon, Hyun Chul Image
Yoon, Hyun Chul윤현철
College of Bio-convergence Engineering
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