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A washing-free immunoassay platform based on the passive movement of retroreflective micro particle and image processing
  • Kim, Ka Ram ;
  • Chun, Hyeong Jin ;
  • Jeong, Kwan Young ;
  • Kim, Jae Ho ;
  • Yoon, Hyun C.
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Publication Year
2018-01-01
Journal
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Publisher
Chemical and Biological Microsystems Society
Citation
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, Vol.2, pp.816-818
Keyword
Image processingRetroreflective optical biosensorWashing-free immunoassay
Mesh Keyword
Cardiac troponinFluidic channelsJanus particlesMicro particlesNon-specific bindingOptical bio-sensorsPassive movementTime lapse images
All Science Classification Codes (ASJC)
Chemistry (all)BioengineeringChemical Engineering (miscellaneous)Control and Systems Engineering
Abstract
In this study, washing-free immunoassay platform on retroreflective optical setup with precise signal distinguishable image processing was established and evaluated for cardiac troponin I. Washing-free immunoassay was enabled due to the passive movement, which is sedimentation property in direction of gravity, of retroreflective Janus particles as time went by. During the assay, sedimentation direction was controlled by simple inverting of the fluidic channel and unreacted RJP would remove by its own specific gravity. In addition, to ensure accuracy, the image processing of time-lapse images were applied to eliminate false signals caused by non-specific binding.
Language
eng
URI
https://aurora.ajou.ac.kr/handle/2018.oak/36352
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85079897767&origin=inward
DOI
https://doi.org/2-s2.0-85079897767
Type
Conference
Funding
This research was supported by the Samsung Research Funding Center of Samsung Electronics under the Project Number SRFC-IT1401-51.This research was supported by the Project Number SRFC-IT1401-51.
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