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Zinc transporters and zinc signaling in skin formation and diseases
  • Bin, Bum Ho ;
  • Lee, Mi Gi ;
  • Hara, Takafumi ;
  • Takagishi, Teruhisa ;
  • Fukada, Toshiyuki
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Publication Year
2020-01-01
Journal
Zinc Signaling
Publisher
Springer Singapore
Citation
Zinc Signaling, pp.305-317
Keyword
DermisEpidermisSkinZinc signalZinc transporter
All Science Classification Codes (ASJC)
Medicine (all)Biochemistry, Genetics and Molecular Biology (all)
Abstract
The skin is the first body region to manifest zinc deficiency. Recent studies have revealed that the zinc transporters, especially zinc importers belonging to the Zrt- Irt-like (ZIP) family, play crucial roles in skin homeostasis. Fourteen ZIP members have been identified in humans, with at least 6 members being related to skin development and maintenance. ZIP1, ZIP2, ZIP4, and ZIP10 are associated with epidermal morphogenesis and disorders, whereas ZIP7 and ZIP13 are essential for dermis formation and collagen metabolism. Mouse models in combination with clinical data have shown the molecular pathogenic mechanisms involving ZIP members. Although other family members have not been well studied with respect to their role in the skin, their direct or indirect associations are also considerable and they are believed to be drug targets for skin diseases. Therefore, precise analysis and understanding of ZIP family members are indispensable for the care and treatment of skin disorders.
Language
eng
URI
https://aurora.ajou.ac.kr/handle/2018.oak/37196
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085450505&origin=inward
DOI
https://doi.org/10.1007/978-981-15-0557-7_15
Journal URL
http://dx.doi.org/10.1007/978-981-15-0557-7
Type
Book Chapter
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Bin, Bum-Ho빈범호
Department of Biological Sciences
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