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Nanofabrication of very-thin self-sustained reduced graphene oxide nanopores for selective protein transport
  • Lee, Dae Sik ;
  • Park, Seokhan ;
  • Han, Yong Duk ;
  • Lee, Jae Eun ;
  • Jeong, Hu Young ;
  • Yoon, Hyun C. ;
  • Kim, Sang Ouk ;
  • Choi, Sung Yool
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Publication Year
2018-01-01
Journal
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Publisher
Chemical and Biological Microsystems Society
Citation
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, Vol.1, pp.586-588
Keyword
Graphene oxideNanoporesProtein transportSelective separation
Mesh Keyword
Fabrication methodFabrication processHuman blood samplesImmunoglobulin GMass producibleProtein transportReduced graphene oxides (RGO)Selective separation
All Science Classification Codes (ASJC)
Chemistry (all)BioengineeringChemical Engineering (miscellaneous)Control and Systems Engineering
Abstract
A new self-suspending nanoporous reduced graphene membrane is designed and fabricated by employing block copolymer (BCP) lithography and dense ultrathin 15 nm-thick nanopore having area (200 micrometer x 200 micrometer) as an super-ultra-high aspect ratio of forty thousand). The preliminary nanopores concept and analysis in Adv. Mater. [1] and a fabrication process part for the device were reported at J. Biomed. Opt. [2]. Our method differs from the previous results [1-2] in the specific working method, basic material, basic design, and fabrication methods. Finally, we have confirmed that the ultrathin 15 nm-thick nanopores are strong enough to be sustain pressures until 1 atm. And they have worked well in separation of hemoglobin (Hb) from a mixed solution of two kinds of proteins, that is immunoglobulin G (IgG) and hemoglobin. They are popular proteins within human blood sample, in a very fast and alternative way. The use of free-standing reduced graphene oxide (rGO) nanosieve will give a simple but mass-producible module for the useful biomolecule isolation giving very high selective results and very fast working speed.
Language
eng
URI
https://aurora.ajou.ac.kr/handle/2018.oak/36353
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85079901014&origin=inward
DOI
https://doi.org/2-s2.0-85079901014
Type
Conference
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