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3D Printing of Poly-ε-Caprolactone (PCL) Auxetic Implants with Advanced Performance for Large Volume Soft Tissue Engineering
  • Park, Jeong Hun ;
  • Park, Hyun Ji ;
  • Tucker, Sarah Jo ;
  • Rutledge, Sarah K. ;
  • Wang, Lizhen ;
  • Davis, Michael E. ;
  • Hollister, Scott J.
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Publication Year
2023-06-12
Journal
Advanced Functional Materials
Publisher
John Wiley and Sons Inc
Citation
Advanced Functional Materials, Vol.33 No.24
Keyword
3D printingauxeticsfinite element analysisselective laser sinteringsoft tissue engineering
Mesh Keyword
3-D printing3D-printingAuxeticsFinite element analyseFinite elements simulationLarge volumesMechanical analysisPerformancePoly(ε caprolactone)Soft tissue engineering
All Science Classification Codes (ASJC)
Electronic, Optical and Magnetic MaterialsChemistry (all)BiomaterialsMaterials Science (all)Condensed Matter PhysicsElectrochemistry
Abstract
A successful 3D printing of a novel 3D architected auxetic for large-volume soft tissue engineering is reported. The 3D auxetic design is analyzed through finite element (FE) simulation and created by selective laser sintering (SLS) of Poly-ε-caprolactone (PCL) for further in-depth mechanical and biological analysis. High initial flexibility and nonlinear stress–strain response to the uniaxial compression are achieved despite the use of PCL, which is one of the biomaterials that is clinically approved but has the disadvantage of having relatively stiff and linear mechanical properties. The high mass transport properties of the 3D auxetic are also demonstrated by not only high cell viability but also cell functionality within a cell-laden hydrogel in large sizes of the auxetic. The outstanding mechanical and biological performance of the 3D auxetic is a consequence of the synergistic effect of the novel architected auxetic design combined with the inherent printing characteristic of SLS. The current study demonstrates great potential of SLS-based printing of 3D auxetics toward the development of clinically viable 3D implants for the reconstruction of large-volume soft tissues.
ISSN
1616-3028
Language
eng
URI
https://aurora.ajou.ac.kr/handle/2018.oak/33298
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150589083&origin=inward
DOI
https://doi.org/2-s2.0-85150589083
Journal URL
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1616-3028
Type
Article
Funding
J.H.P. and H.\u2010J.P. contributed equally to this work. This research was supported by the US National Institutes of Health (NIH) (R01 HD 086201). In addition, H.\u2010J.P. acknowledges the support from American Heart Association (AHA) Postdoctoral Fellowship (837187).
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Park, Hyun Ji박현지
College of Bio-convergence Engineering
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