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miR-31-3p functions as a tumor suppressor by directly targeting GABBR2 in prostate canceroa mark
  • Choi, Sujin ;
  • Lee, Soonchul ;
  • Han, Young Hoon ;
  • Choi, Junwon ;
  • Kim, Isaac ;
  • Lee, Jusung ;
  • An, Hyun Ju
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Publication Year
2022-08-18
Journal
Frontiers in Oncology
Publisher
Frontiers Media SA
Citation
Frontiers in Oncology, Vol.12
Keyword
GABBR2miR-31-3pmiRNAprostate cancertumor suppressor gene
All Science Classification Codes (ASJC)
OncologyCancer Research
Abstract
MicroRNAs are key regulators of gene expression in tumorigenesis. In this study, we investigated the tumor-suppressive function of miR-31-3p. Analysis of the Gene Expression Omnibus database revealed that the expression of miR-31-3p in prostate cancer tissues is lower than that in adjacent normal tissues from patients with prostate cancer. Moreover, miR-31-3p induces apoptosis in DU145, PC-3, and LNCap prostate cancer cells, while those transfected with miR-31-3p exhibit significantly decreased cell proliferation, migration, invasiveness, and tumor sphere-forming ability, as determined using the cell counting kit-8, transwell, and sphere-forming assays. Further analysis revealed that GABBR2 is a direct target of miR-31-3p. Within a DU145 xenograft murine model, intratumoral injection of a miR-31-3p mimic suppresses tumor growth. Taken together, the findings of this study suggest that miR-31-3p performs a novel tumor-suppressive function in prostate cancer and may represent a novel target for anti-prostate cancer miRNA therapeutics.
ISSN
2234-943X
Language
eng
URI
https://aurora.ajou.ac.kr/handle/2018.oak/32910
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137806366&origin=inward
DOI
https://doi.org/2-s2.0-85137806366
Journal URL
http://www.frontiersin.org/Oncology/about
Type
Article
Funding
This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(No. 2020R1I1A1A01073917).
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Choi, Jun Won최준원
College of Bio-convergence Engineering
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