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miR-31-3p functions as a tumor suppressor by directly targeting GABBR2 in prostate canceroa mark
  • Choi, Sujin ;
  • Lee, Soonchul ;
  • Han, Young Hoon ;
  • Choi, Junwon ;
  • Kim, Isaac ;
  • Lee, Jusung ;
  • An, Hyun Ju
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dc.contributor.authorChoi, Sujin-
dc.contributor.authorLee, Soonchul-
dc.contributor.authorHan, Young Hoon-
dc.contributor.authorChoi, Junwon-
dc.contributor.authorKim, Isaac-
dc.contributor.authorLee, Jusung-
dc.contributor.authorAn, Hyun Ju-
dc.date.issued2022-08-18-
dc.identifier.issn2234-943X-
dc.identifier.urihttps://aurora.ajou.ac.kr/handle/2018.oak/32910-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137806366&origin=inward-
dc.description.abstractMicroRNAs are key regulators of gene expression in tumorigenesis. In this study, we investigated the tumor-suppressive function of miR-31-3p. Analysis of the Gene Expression Omnibus database revealed that the expression of miR-31-3p in prostate cancer tissues is lower than that in adjacent normal tissues from patients with prostate cancer. Moreover, miR-31-3p induces apoptosis in DU145, PC-3, and LNCap prostate cancer cells, while those transfected with miR-31-3p exhibit significantly decreased cell proliferation, migration, invasiveness, and tumor sphere-forming ability, as determined using the cell counting kit-8, transwell, and sphere-forming assays. Further analysis revealed that GABBR2 is a direct target of miR-31-3p. Within a DU145 xenograft murine model, intratumoral injection of a miR-31-3p mimic suppresses tumor growth. Taken together, the findings of this study suggest that miR-31-3p performs a novel tumor-suppressive function in prostate cancer and may represent a novel target for anti-prostate cancer miRNA therapeutics.-
dc.description.sponsorshipThis research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(No. 2020R1I1A1A01073917).-
dc.language.isoeng-
dc.publisherFrontiers Media SA-
dc.titlemiR-31-3p functions as a tumor suppressor by directly targeting GABBR2 in prostate cancer-
dc.typeArticle-
dc.citation.titleFrontiers in Oncology-
dc.citation.volume12-
dc.identifier.bibliographicCitationFrontiers in Oncology, Vol.12-
dc.identifier.doi2-s2.0-85137806366-
dc.identifier.scopusid2-s2.0-85137806366-
dc.identifier.urlhttp://www.frontiersin.org/Oncology/about-
dc.subject.keywordGABBR2-
dc.subject.keywordmiR-31-3p-
dc.subject.keywordmiRNA-
dc.subject.keywordprostate cancer-
dc.subject.keywordtumor suppressor gene-
dc.type.otherArticle-
dc.description.isoatrue-
dc.subject.subareaOncology-
dc.subject.subareaCancer Research-
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College of Bio-convergence Engineering
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