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DC Field | Value | Language |
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dc.contributor.author | Choi, Sujin | - |
dc.contributor.author | Lee, Soonchul | - |
dc.contributor.author | Han, Young Hoon | - |
dc.contributor.author | Choi, Junwon | - |
dc.contributor.author | Kim, Isaac | - |
dc.contributor.author | Lee, Jusung | - |
dc.contributor.author | An, Hyun Ju | - |
dc.date.issued | 2022-08-18 | - |
dc.identifier.issn | 2234-943X | - |
dc.identifier.uri | https://aurora.ajou.ac.kr/handle/2018.oak/32910 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137806366&origin=inward | - |
dc.description.abstract | MicroRNAs are key regulators of gene expression in tumorigenesis. In this study, we investigated the tumor-suppressive function of miR-31-3p. Analysis of the Gene Expression Omnibus database revealed that the expression of miR-31-3p in prostate cancer tissues is lower than that in adjacent normal tissues from patients with prostate cancer. Moreover, miR-31-3p induces apoptosis in DU145, PC-3, and LNCap prostate cancer cells, while those transfected with miR-31-3p exhibit significantly decreased cell proliferation, migration, invasiveness, and tumor sphere-forming ability, as determined using the cell counting kit-8, transwell, and sphere-forming assays. Further analysis revealed that GABBR2 is a direct target of miR-31-3p. Within a DU145 xenograft murine model, intratumoral injection of a miR-31-3p mimic suppresses tumor growth. Taken together, the findings of this study suggest that miR-31-3p performs a novel tumor-suppressive function in prostate cancer and may represent a novel target for anti-prostate cancer miRNA therapeutics. | - |
dc.description.sponsorship | This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(No. 2020R1I1A1A01073917). | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media SA | - |
dc.title | miR-31-3p functions as a tumor suppressor by directly targeting GABBR2 in prostate cancer | - |
dc.type | Article | - |
dc.citation.title | Frontiers in Oncology | - |
dc.citation.volume | 12 | - |
dc.identifier.bibliographicCitation | Frontiers in Oncology, Vol.12 | - |
dc.identifier.doi | 2-s2.0-85137806366 | - |
dc.identifier.scopusid | 2-s2.0-85137806366 | - |
dc.identifier.url | http://www.frontiersin.org/Oncology/about | - |
dc.subject.keyword | GABBR2 | - |
dc.subject.keyword | miR-31-3p | - |
dc.subject.keyword | miRNA | - |
dc.subject.keyword | prostate cancer | - |
dc.subject.keyword | tumor suppressor gene | - |
dc.type.other | Article | - |
dc.description.isoa | true | - |
dc.subject.subarea | Oncology | - |
dc.subject.subarea | Cancer Research | - |
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