This research was supported by the Ajou University Research Fund and by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (grant number RS-2021-NR060141 to B-HB). We would like to thank Irene Valenzuela and Andrea Superti-Furga for their invaluable insights and constructive feedback during the preparation of this manuscript. B-HB serves as a guarantor of this manuscript. Conceptualization: SB, MS, B-HB; Funding Acquisition: B-HB; Investigation: SB, GHL, GP, VC, GV, FZ, J-YK, SKC, BS, JK, J-HP, MS; Methodology: SB, J-YK, SKC, B-HB; Project Administration: BMW, MS, B-HB; Writing - Original Draft Preparation: SB, MS, B-HB