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Injectable In Situ-Forming Hydrogels for Protein and Peptide Delivery
  • Park, Seung Hun ;
  • Ji, Yun Bae ;
  • Park, Joon Yeong ;
  • Ju, Hyeon Jin ;
  • Lee, Mijeong ;
  • Lee, Surha ;
  • Kim, Jae Ho ;
  • Min, Byoung Hyun ;
  • Kim, Moon Suk
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Publication Year
2020-01-01
Journal
Advances in Experimental Medicine and Biology
Publisher
Springer
Citation
Advances in Experimental Medicine and Biology, Vol.1250, pp.35-48
Keyword
Biomedical application of hydrogelClick reactionCovalent and non-covalent bondingCrosslinkingDrug delivery systemDrug depotElectrostatic interactionInjectable in situ forming hydrogelsPhysical interactionProtein and peptideProtein and peptide loading
Mesh Keyword
Drug Delivery SystemsHumansHydrogelsInjectionsPeptidesProteins
All Science Classification Codes (ASJC)
Biochemistry, Genetics and Molecular Biology (all)
Abstract
Injectable in situ-forming hydrogels have been used clinically in diverse biomedical applications. These hydrogels have distinct advantages such as easy management and minimal invasiveness. The hydrogels are aqueous formulations, and a simple injection at the target site replaces a traditional surgical procedure. Here, we review injectable in situ-forming hydrogels that are formulated by physical and chemical methods to deliver proteins and peptides. Prospects for using in situ-forming hydrogels for several specific applications are also discussed.
ISSN
2214-8019
Language
eng
URI
https://aurora.ajou.ac.kr/handle/2018.oak/34721
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087397314&origin=inward
DOI
https://doi.org/10.1007/978-981-15-3262-7_3
Journal URL
http://www.springer.com/series/5584
Type
Book Chapter
Funding
This study was supported by a grant from Creative Materials Discovery Program through the National Research Foundation (2019M3D1A1078938) and Priority Research Centers Program (2019R1A6A1A11051471) funded by the National Research Foundation of Korea (NRF).
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Kim, Moon Suk김문석
Department of Applied Chemistry & Biological Engineering
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