Ajou University repository

Enhancement of Sensitivity for Retroreflection-Based Biosensor by Controlling Polymer Brush on Janus Particles
Citations

SCOPUS

0

Citation Export

Publication Year
2024-04-01
Journal
Macromolecular Chemistry and Physics
Publisher
John Wiley and Sons Inc
Citation
Macromolecular Chemistry and Physics, Vol.225 No.7
Keyword
biosensorcolloidJanus particlespolymer brushretroreflective sensor
Mesh Keyword
Bio photonicsFunctionalizedJanus particlesOn-site detectionPolymer brushesPropertyRetro reflectionRetroreflective sensorsSensing abilitiesSimple++
All Science Classification Codes (ASJC)
Condensed Matter PhysicsPhysical and Theoretical ChemistryPolymers and PlasticsOrganic ChemistryMaterials Chemistry
Abstract
Among the methods for onsite detection of specific biomolecules, the use of retroreflective Janus particles (RJPs) is a simple and efficient method for biophotonic probes to detect biotarget molecules with spatioselectivity, which can make the RJPs align toward light sources after capturing the target biomolecules, enhancing retroreflection. Because RJP has two distinct regions with different properties, specific reagents can be easily functionalized through chemical reactions between the functional groups and biotarget molecules. The number of functional groups on RJP will be the critical parameter for efficiency of sensing ability. Here, clickable (azide) polymer brush is introduced on surface of RJP via different surface polymerization methods (grafting to and grafting from method). Azide groups allow for the easy modification of dibenzocyclooctyne-linked biomolecules onto silica particles through click chemistry. RJPs are prepared with different quantities of azide functional groups on their surfaces via solvent volatilization method and metal deposition. Using a retroreflective immunosensing system, sensitive detection of target biomolecules is performed.
ISSN
1521-3935
Language
eng
URI
https://aurora.ajou.ac.kr/handle/2018.oak/33900
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85182448286&origin=inward
DOI
https://doi.org/10.1002/macp.202300382
Journal URL
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-3935
Type
Article
Funding
This research was supported by the Challengeable Future Defense Technology Research and Development Program through the Agency for Defense Development (ADD) funded by the Defense Acquisition Program Administration in 2021 (UI220005TD).
Show full item record

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Yoo, Tae Hyeon Image
Yoo, Tae Hyeon유태현
College of Bio-convergence Engineering
Read More

Total Views & Downloads

File Download

  • There are no files associated with this item.