This research was supported by the Ajou University Research Fund, the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant number NRF-2021R1A6A1A10044950 to B-HB), the Korea Initiative for fostering University of Research and Innovation Program funded by the Ministry of Science and ICT through NRF (number NRF2021M3H1A104892211 to B-HB and B-MK), the Ministry of Science and ICT (grants numbers 2023M3A9A700944231 to J-HP and 2019R1A6A1A03033215 to BMW), and by the Bio & Medical Technology Development Program through NRF (grants numbers 2014M3A9D5A01075128 to HL and 2013M3A9D5072550 to JKS). Conceptualization: SB, HH; Funding Acquisition: B-HB, B-MK, J-HP, BMW, HL, JKS; Investigation: SB, HH, BC, SHL, GP, JKS, HL; Methodology: SB, HH, BC, SHL, GP; Project Administration: B-MK, J-HP, B-HB; Supervision: J-HP, BMW, B-HB; Validation: B-MK, BMW, B-HB; Writing - Original Draft Preparation: SB, HH; Writing – Review and Editing: B-HB.This research was supported by the Ajou University Research Fund, the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant number NRF-2021R1A6A1A10044950 to B-HB), the Korea Initiative for fostering University of Research and Innovation Program funded by the Ministry of Science and ICT through NRF (number NRF2021M3H1A104892211 to B-HB and B-MK), the Ministry of Science and ICT (grants numbers 2023M3A9A700944231 to J-HP and 2019R1A6A1A03033215 to BMW), and by the Bio & Medical Technology Development Program through NRF (grants numbers 2014M3A9D5A01075128 to HL and 2013M3A9D5072550 to JKS).