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Imidazole-carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging
  • Pham, Thanh Chung ;
  • Lee, Dong Joon ;
  • Kim, Do Hun ;
  • Yoon, Juyoung ;
  • Lam, Tran Dai ;
  • Kim, Hwan Myung ;
  • Lee, Songyi
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Publication Year
2023-03-20
Journal
Chemical Communications
Publisher
Royal Society of Chemistry
Citation
Chemical Communications, Vol.59 No.30, pp.4503-4506
Mesh Keyword
Bio-imagingFluorescence emissionHeavy atomsHeLa cellImidazolPhotosensitiserTwo-photon excitationsTwo-photon excitedCarbazolesFluorescenceHeLa CellsHumansImidazolesPhotochemotherapy
All Science Classification Codes (ASJC)
Electronic, Optical and Magnetic MaterialsCatalysisCeramics and CompositesChemistry (all)Surfaces, Coatings and FilmsMetals and AlloysMaterials Chemistry
Abstract
A heavy-atom-free photosensitizer (CI) based on an imidazole-carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm) toward HeLa cells with negligible dark toxicity.
ISSN
1364-548X
Language
eng
URI
https://aurora.ajou.ac.kr/handle/2018.oak/33335
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85151826209&origin=inward
DOI
https://doi.org/2-s2.0-85151826209
Journal URL
http://pubs.rsc.org/en/journals/journal/cc
Type
Article
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Kim, Hwan Myung김환명
Department of Chemistry
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