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Decoding the rosetta stone of mitonuclear communicationoa mark
  • English, Justin ;
  • Son, Jyung Mean ;
  • Cardamone, Maria Dafne ;
  • Lee, Changhan ;
  • Perissi, Valentina
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Publication Year
2020-11-01
Journal
Pharmacological Research
Publisher
Academic Press
Citation
Pharmacological Research, Vol.161
Keyword
Acetyl-Coenzyme A (PubChem CID: 6302)Alpha-ketoglutarate (PubChem CID: 164533)Antimycin (PubChem CID: 12550)Carbonyl cyanide m-chlorophenylhydrazone (CCCP) (PubChem CID: 2603)CommunicationEpigeneticsHumanin (PubChem CID: 16131438)Integrated stress responseMitochondrial retrograde signalingMitonuclearNicotinamide riboside (PubChem CID: 439924)Oligoymycin (PubChem CID: 78358496)S-adenosylmethionine (SAM) (PubChem CID: 34756)Superoxide anion (PubChem CID: 5359597)
Mesh Keyword
AnimalsCell CommunicationCell NucleusGene Expression RegulationHumansMitochondriaMitochondrial ProteinsNuclear ProteinsSignal Transduction
All Science Classification Codes (ASJC)
Pharmacology
Abstract
Cellular homeostasis in eukaryotic cells requires synchronized coordination of multiple organelles. A key role in this stage is played by mitochondria, which have recently emerged as highly interconnected and multifunctional hubs that process and coordinate diverse cellular functions. Beyond producing ATP, mitochondria generate key metabolites and are central to apoptotic and metabolic signaling pathways. Because most mitochondrial proteins are encoded in the nuclear genome, the biogenesis of new mitochondria and the maintenance of mitochondrial functions and flexibility critically depend upon effective mitonuclear communication. This review addresses the complex network of signaling molecules and pathways allowing mitochondria-nuclear communication and coordinated regulation of their independent but interconnected genomes, and discusses the extent to which dynamic communication between the two organelles has evolved for mutual benefit and for the overall maintenance of cellular and organismal fitness.
ISSN
1096-1186
Language
eng
URI
https://aurora.ajou.ac.kr/handle/2018.oak/31500
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85090030609&origin=inward
DOI
https://doi.org/10.1016/j.phrs.2020.105161
Journal URL
http://www.elsevier.com/inca/publications/store/6/2/2/9/3/1/index.htt
Type
Article
Funding
We are grateful to members of the Perissi and Lee labs for discussions and feedbacks. This work is funded by NIH R01GM127625 to VP, NIH R01AG052258 to CL, KGCRF to MDC, NIH 5T32GM008541 to JE, and an AFAR fellowship to JMS.We are grateful to members of the Perissi and Lee labs for discussions and feedbacks. This work is funded by NIHR01GM127625 to VP, NIHR01AG052258 to CL, KGCRF to MDC, NIH5T32GM008541 to JE, and an AFAR fellowship to JMS.
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Department of Biological Sciences
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