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Tissue-specific role of CX3CR1 expressing immune cells and their relationships with human diseaseoa mark
  • Lee, Myoungsoo ;
  • Lee, Yongsung ;
  • Song, Jihye ;
  • Lee, Junhyung ;
  • Chang, Sun Young
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Publication Year
2018-02-01
Journal
Immune Network
Publisher
Korean Association of Immunologists
Citation
Immune Network, Vol.18 No.1
Keyword
CX3CL1CX3CR1MacrophagesMonocytesTissue specificity
All Science Classification Codes (ASJC)
Immunology and AllergyImmunologyInfectious Diseases
Abstract
Chemokine (C-X3-C motif) ligand 1 (CX3CL1, also known as fractalkine) and its receptor chemokine (C-X3-C motif) receptor 1 (CX3CR1) are widely expressed in immune cells and non-immune cells throughout organisms. However, their expression is mostly cell type-specific in each tissue. CX3CR1 expression can be found in monocytes, macrophages, dendritic cells, T cells, and natural killer (NK) cells. Interaction between CX3CL1 and CX3CR1 can mediate chemotaxis of immune cells according to concentration gradient of ligands. CX3CR1 expressing immune cells have a main role in either pro-inflammatory or anti-inflammatory response depending on environmental condition. In a given tissue such as bone marrow, brain, lung, liver, gut, and cancer, CX3CR1 expressing cells can maintain tissue homeostasis. Under pathologic conditions, however, CX3CR1 expressing cells can play a critical role in disease pathogenesis. Here, we discuss recent progresses of CX3CL1/CX3CR1 in major tissues and their relationships with human diseases.
ISSN
2092-6685
Language
eng
URI
https://aurora.ajou.ac.kr/handle/2018.oak/30116
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85042780329&origin=inward
DOI
https://doi.org/2-s2.0-85042780329
Journal URL
https://www.immunenetwork.org/Synapse/Data/PDFData/0078IN/in-18-e5.pdf
Type
Article
Funding
This work was supported by the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT and future Planning (NRF-2017R1A2B4002419) and a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant number HI15C1980).
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