In this study, web address (URL) encoded orodispersible film was designed and printed by Hot melt extruding method using air-pressure based 3D printer. This film contained a poorly water-soluble drug, Paliperidone Palmitate (PPP). This research aimed to determine manufacturing conditions with a high recognition rate (%) and formulation which can disintegrate immediately and have increased solubility. The film was formed by optimizing the ratio of polyethylene oxide (PEO), poloxamer 188, polyethylene glycol (PEG) 4000, and polysorbate 20, Citric acid, and PPP. Nozzle diameter, printing rate, pressure value, printing temperature, and aging time were controlled to print the surface evenly and the QR code in detail. QR code recognition rate (%) of the optimized formulation (F4) was 96.67±2.89%. Physicochemical properties were evaluated by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), and X-ray Diffraction (XRD). The dissolution test was performed under the USP Apparatus type II method in pH 1.2 buffer solution with 0.489% polysorbate 20. Drug-loaded URL-QRODF was recognizable by a smartphone camera. The recognition rate (%) was 96.67±2.89%, which was high enough for daily life. Drug release from the film immediately reached more than 85% and the disintegration time was 17.3±0.7 seconds which means ‘orodispersible’. Patient-centered drug-loaded URL-QRODF that can be connected to any network was devised.
