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Highly selective two-photon fluorescent off-on probes for imaging tyrosinase activity in living cells and tissues
  • Cui, Yixin ;
  • Park, Sang Jun ;
  • Wu, Xiaofeng ;
  • Wang, Rui ;
  • Qi, Sujie ;
  • Kim, Hwan Myung ;
  • Yoon, Juyoung

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Publication Year
2021-07-18
Publisher
Royal Society of Chemistry
Citation
Chemical Communications, Vol.57, pp.6911-6914
Mesh Keyword
High selectivityLive cellLiving cellTwo photonAnimalsCell Line, TumorCoumarinsDrug DesignFluorescent DyesHumansLimit of DetectionMiceMicroscopy, Fluorescence, MultiphotonMonophenol MonooxygenasePhotonsRats
All Science Classification Codes (ASJC)
CatalysisElectronic, Optical and Magnetic MaterialsCeramics and CompositesChemistry (all)Surfaces, Coatings and FilmsMetals and AlloysMaterials Chemistry
Abstract
A coumarin-based two-photon (TP) fluorescent off-on probe has been developed for detecting tyrosinase activity. High selectivity, sensitivity and biocompatibility enable the probes to successfully image tyrosinase activity in live cells and tissues using TP microscopy.
Language
eng
URI
https://dspace.ajou.ac.kr/dev/handle/2018.oak/32142
DOI
https://doi.org/10.1039/d1cc02374h
Fulltext

Type
Article
Funding
J. Yoon is grateful for financial support from the National Research foundation of Korea (NRF), which was funded by the Korea government (MSIP) (No. 2012R1A3A2048814). H. M. K. acknowledges a grant from the National Leading Research Lab Program of the NRF, funded by the Korea government (MSIP) (NRF-2019R1A2B5B03100278).
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Kim, Hwan Myung김환명
Department of Chemistry
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