The development and application of a novel endo furan-protected maleimide building block is reported. The endo isomer undergoes deprotection at temperatures ∼50 °C below the exo derivative. This enables a simple and powerful approach to quantitatively and selectively introduce functional maleimide groups via temperature modulation.
J.R.A. and C.J.H. acknowledge support from the UCSB MRSEC (NSF DMR 1720256). E.H.D. thanks the NSF Graduate Research Fellowship and the UCSB graduate division, Graduate Research Mentorship Program (GRMP) fellowship for financial support. A.H.S. thanks the Natural Sciences and Engineering Research Council of Canada (NSERC) for a postgraduate scholarship (PGS-D). S.N.N. thanks the MARC scholars program.
