Ajou University repository

Journal of Medicinal Chemistry
ISSN
  • E1520-4804
  • P0022-2623
Publisher

American Chemical Society

Listed on
(Coverage)

JCR1997-2023

SJR1999-2020;2022-2023

CiteScore2011-2023

SCI2010-2019

SCIE2010-2024

CC2016-2024

SCOPUS2017-2024

MEDLINE2016-2024

EMBASE2016-2024

Active
Active

based on the information

  • SCOPUS:2024-10
Country
USA
Aime & Scopes
The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action. Some specific areas that are appropriate include the following: /// Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools. /// Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication. /// Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds. /// Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition. /// Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge. /// Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules. /// Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds. This may include design, synthesis, and evaluation of novel types of prodrugs. /// Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.
Article List

Showing results 1 to 3 of 3

Discovery of Orally Bioavailable Phthalazinone Analogues as an ENPP1 Inhibitor for STING-Mediated Cancer Immunotherapy
  • Cho, Yeonguk;
  • Kang, Miso;
  • Ji, Su Hyun;
  • Jeong, Hee Jin;
  • Jung, Jae Eun;
  • Oh, Do Hee;
  • Park, Sunyoung;
  • Park, Yong Yea;
  • Choi, Junghwan;
  • Kim, Sungjoon;
et al
  • 2023-11-23
  • Journal of Medicinal Chemistry, Vol.66 No.22, pp.15141-15170
  • American Chemical Society
Redirection of CAR-T Cell Cytotoxicity Using Metabolic Glycan Labeling with Unnatural Sugars
  • Cha, Jeong Hyeon;
  • Kim, Eunsu;
  • Lee, Hyeong Ji;
  • Lee, Young Ho;
  • Lee, Jeonghyun;
  • Kim, Eunha;
  • Kim, Chan Hyuk
  • 2023-06-22
  • Journal of Medicinal Chemistry, Vol.66 No.12, pp.7804-7812
  • American Chemical Society
Linear and rationally designed stapled peptides abrogate TLR4 pathway and relieve inflammatory symptoms in rheumatoid arthritis rat model
  • Achek, Asma;
  • Shah, Masaud;
  • Seo, Ji Young;
  • Kwon, Hyuk Kwon;
  • Gui, Xiangai;
  • Shin, Hyeon Jun;
  • Cho, Eun Young;
  • Lee, Byeong Sung;
  • Kim, Dong Jin;
  • Lee, Sang Ho;
et al
  • 2019-07-25
  • Journal of Medicinal Chemistry, Vol.62 No.14, pp.6495-6511
  • American Chemical Society
1