Deduplication is a data redundancy elimination technique, designed to save system storage resources by reducing redundant data in cloud storage systems. With the development of cloud computing technology, deduplication has been increasingly applied to cloud data centers. However, traditional technologies face great challenges in big data deduplication to properly weigh the two conflicting goals of deduplication throughput and high duplicate elimination ratio. This paper proposes a similarity clustering-based deduplication strategy (named SCDS), which aims to delete more duplicate data without significantly increasing system overhead. The main idea of SCDS is to narrow the query range of fingerprint index by data partitioning and similarity clustering algorithms. In the data preprocessing stage, SCDS uses data partitioning algorithm to classify similar data together. In the data deletion stage, the similarity clustering algorithm is used to divide the similar data fingerprint superblock into the same cluster. Repetitive fingerprints are detected in the same cluster to speed up the retrieval of duplicate fingerprints. Experiments show that the deduplication ratio of SCDS is better than some existing similarity deduplication algorithms, but the overhead is only slightly higher than some high throughput but low deduplication ratio methods.