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High payload dexamethasone palmitate-loaded solid lipid nanoparticles for enhanced anti-inflammatory effects in acute skin inflammation model
  • Bae, Yumi ;
  • Zeb, Alam ;
  • Choi, Ho Ik ;
  • Ryu, Jeong Su ;
  • Gul, Maleeha ;
  • Noh, Ha Yeon ;
  • Cho, Junho ;
  • Gil, Junkyung ;
  • Shah, Fawad Ali ;
  • Chang, Sun Young ;
  • Bae, Ok Nam ;
  • Kim, Jin Ki
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dc.contributor.authorBae, Yumi-
dc.contributor.authorZeb, Alam-
dc.contributor.authorChoi, Ho Ik-
dc.contributor.authorRyu, Jeong Su-
dc.contributor.authorGul, Maleeha-
dc.contributor.authorNoh, Ha Yeon-
dc.contributor.authorCho, Junho-
dc.contributor.authorGil, Junkyung-
dc.contributor.authorShah, Fawad Ali-
dc.contributor.authorChang, Sun Young-
dc.contributor.authorBae, Ok Nam-
dc.contributor.authorKim, Jin Ki-
dc.date.issued2024-09-01-
dc.identifier.issn2093-6214-
dc.identifier.urihttps://aurora.ajou.ac.kr/handle/2018.oak/34033-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85188112287&origin=inward-
dc.description.abstractPurpose: Dexamethasone palmitate (DXPL) is a lipophilic derivative of dexamethasone (DXM) used to overcome the low drug-loading capacity and immediate release characteristics of DXM from nanoparticles. In this study, we investigated the potential of DXPL-loaded solid lipid nanoparticles (DXPL-SLNs) to increase drug encapsulation efficiency, prolong drug release, and alleviate skin inflammation. Methods: DXPL-SLNs were prepared using the nano-emulsion template technique with trilaurin as a lipid matrix and Tween 20, Span 20, and Brij 58 as a surfactant mixture. The physicochemical properties of DXPL-SLNs were examined in terms of particle size, polydispersity index, zeta potential, encapsulation efficiency, loading capacity, morphology, and crystalline behavior. The in vitro release profile of DXM from the DXPL-SLNs incubated in mouse plasma was assessed using a plasma conversion assay. In vivo anti-inflammatory effects of topically applied DXPL-SLNs were evaluated in mice with 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ear edema. Results: The optimized DXPL-SLNs (DXPL/trilaurin/Tween 20/Span 20/Brij 58:4/2/2/0.2/4, w/w ratio, respectively) displayed a mean particle size of 182.8 ± 2.7 nm with a very high drug loading capacity of 30.4%. DXPL-SLNs showed substantially prolonged drug release in mouse plasma compared to DXPL solution. Furthermore, DXPL-SLNs showed enhanced anti-inflammatory effects by efficiently reducing TPA-induced ear edema. Conclusion: These findings suggest that DXPL-SLNs have great potential as anti-inflammatory therapeutics against acute skin inflammation.-
dc.description.sponsorshipThis work was supported by the Materials/Parts Technology Development Program (Development of industry process of a new hyaluronic acid, 200 Pa\u00b7s or more, of more than 20 times compared to the existing for sustained-release DDS, 1415184765, 20016715) funded by the Ministry of Trade, Industry and Energy (MOTIE, Korea).-
dc.language.isoeng-
dc.publisherSpringer-
dc.titleHigh payload dexamethasone palmitate-loaded solid lipid nanoparticles for enhanced anti-inflammatory effects in acute skin inflammation model-
dc.typeArticle-
dc.citation.endPage629-
dc.citation.number5-
dc.citation.startPage617-
dc.citation.titleJournal of Pharmaceutical Investigation-
dc.citation.volume54-
dc.identifier.bibliographicCitationJournal of Pharmaceutical Investigation, Vol.54 No.5, pp.617-629-
dc.identifier.doi10.1007/s40005-024-00674-x-
dc.identifier.scopusid2-s2.0-85188112287-
dc.identifier.urlhttps://www.springer.com/journal/40005-
dc.subject.keywordAnti-inflammatory-
dc.subject.keywordDexamethasone-
dc.subject.keywordDexamethasone palmitate-
dc.subject.keywordEar edema-
dc.subject.keywordSkin inflammation-
dc.subject.keywordSolid lipid nanoparticles-
dc.type.otherArticle-
dc.identifier.pissn2093-5552-
dc.description.isoafalse-
dc.subject.subareaPharmaceutical Science-
dc.subject.subareaPharmacology, Toxicology and Pharmaceutics (miscellaneous)-
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