Citation Export
DC Field | Value | Language |
---|---|---|
dc.contributor.author | In, Kyu Ree | - |
dc.contributor.author | Kang, Mi Ae | - |
dc.contributor.author | Kim, Su Dong | - |
dc.contributor.author | Shin, Jinho | - |
dc.contributor.author | Kang, Sung Un | - |
dc.contributor.author | Park, Tae Jun | - |
dc.contributor.author | Kim, Seung Joo | - |
dc.contributor.author | Lee, Jong Soo | - |
dc.date.issued | 2023-10-01 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://aurora.ajou.ac.kr/handle/2018.oak/33739 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85174675993&origin=inward | - |
dc.description.abstract | Melanogenesis, the intricate process of melanin synthesis, is central to skin pigmentation and photoprotection and is regulated by various signaling pathways and transcription factors. To develop potential skin-whitening agents, we used B16F1 melanoma cells to investigate the inhibitory effects of anhydrous alum on melanogenesis and its underlying molecular mechanisms. Anhydrous alum (KAl(SO4)2) with high purity (>99%), which is generated through the heat-treatment of hydrated alum (KAl(SO4)2·12H2O) at 400 °C, potentiates a significant reduction in melanin content without cytotoxicity. Anhydrous alum downregulates the master regulator of melanogenesis, microphthalmia-associated transcription factor (MITF), which targets key genes involved in melanogenesis, thereby inhibiting α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis. Phosphorylation of the cAMP response element-binding protein, which acts as a co-activator of MITF gene expression, is attenuated by anhydrous alum, resulting in compromised MITF transcription. Notably, anhydrous alum promoted extracellular signal-regulated kinase phosphorylation, leading to the impaired nuclear localization of MITF. Overall, these results demonstrated the generation and mode of action of anhydrous alum in B16F1 cells, which constitutes a promising option for cosmetic or therapeutic use. | - |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (NRF-2021R1A6A1A10044950 and 2020R1A2C201130214). | - |
dc.language.iso | eng | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.subject.mesh | alpha-MSH | - |
dc.subject.mesh | Cell Line, Tumor | - |
dc.subject.mesh | Melanins | - |
dc.subject.mesh | Microphthalmia-Associated Transcription Factor | - |
dc.subject.mesh | Monophenol Monooxygenase | - |
dc.title | Anhydrous Alum Inhibits α-MSH-Induced Melanogenesis by Down-Regulating MITF via Dual Modulation of CREB and ERK | - |
dc.type | Article | - |
dc.citation.number | 19 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 24 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, Vol.24 No.19 | - |
dc.identifier.doi | 2-s2.0-85174675993 | - |
dc.identifier.pmid | 37834109 | - |
dc.identifier.scopusid | 2-s2.0-85174675993 | - |
dc.identifier.url | http://www.mdpi.com/journal/ijms | - |
dc.subject.keyword | anhydrous alum | - |
dc.subject.keyword | CREB | - |
dc.subject.keyword | ERK | - |
dc.subject.keyword | melanogenesis | - |
dc.subject.keyword | MITF | - |
dc.type.other | Article | - |
dc.identifier.pissn | 1661-6596 | - |
dc.description.isoa | true | - |
dc.subject.subarea | Catalysis | - |
dc.subject.subarea | Molecular Biology | - |
dc.subject.subarea | Spectroscopy | - |
dc.subject.subarea | Computer Science Applications | - |
dc.subject.subarea | Physical and Theoretical Chemistry | - |
dc.subject.subarea | Organic Chemistry | - |
dc.subject.subarea | Inorganic Chemistry | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.