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Anhydrous Alum Inhibits α-MSH-Induced Melanogenesis by Down-Regulating MITF via Dual Modulation of CREB and ERKoa mark
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dc.contributor.authorIn, Kyu Ree-
dc.contributor.authorKang, Mi Ae-
dc.contributor.authorKim, Su Dong-
dc.contributor.authorShin, Jinho-
dc.contributor.authorKang, Sung Un-
dc.contributor.authorPark, Tae Jun-
dc.contributor.authorKim, Seung Joo-
dc.contributor.authorLee, Jong Soo-
dc.date.issued2023-10-01-
dc.identifier.issn1422-0067-
dc.identifier.urihttps://aurora.ajou.ac.kr/handle/2018.oak/33739-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85174675993&origin=inward-
dc.description.abstractMelanogenesis, the intricate process of melanin synthesis, is central to skin pigmentation and photoprotection and is regulated by various signaling pathways and transcription factors. To develop potential skin-whitening agents, we used B16F1 melanoma cells to investigate the inhibitory effects of anhydrous alum on melanogenesis and its underlying molecular mechanisms. Anhydrous alum (KAl(SO4)2) with high purity (>99%), which is generated through the heat-treatment of hydrated alum (KAl(SO4)2·12H2O) at 400 °C, potentiates a significant reduction in melanin content without cytotoxicity. Anhydrous alum downregulates the master regulator of melanogenesis, microphthalmia-associated transcription factor (MITF), which targets key genes involved in melanogenesis, thereby inhibiting α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis. Phosphorylation of the cAMP response element-binding protein, which acts as a co-activator of MITF gene expression, is attenuated by anhydrous alum, resulting in compromised MITF transcription. Notably, anhydrous alum promoted extracellular signal-regulated kinase phosphorylation, leading to the impaired nuclear localization of MITF. Overall, these results demonstrated the generation and mode of action of anhydrous alum in B16F1 cells, which constitutes a promising option for cosmetic or therapeutic use.-
dc.description.sponsorshipThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (NRF-2021R1A6A1A10044950 and 2020R1A2C201130214).-
dc.language.isoeng-
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)-
dc.subject.meshalpha-MSH-
dc.subject.meshCell Line, Tumor-
dc.subject.meshMelanins-
dc.subject.meshMicrophthalmia-Associated Transcription Factor-
dc.subject.meshMonophenol Monooxygenase-
dc.titleAnhydrous Alum Inhibits α-MSH-Induced Melanogenesis by Down-Regulating MITF via Dual Modulation of CREB and ERK-
dc.typeArticle-
dc.citation.number19-
dc.citation.titleInternational Journal of Molecular Sciences-
dc.citation.volume24-
dc.identifier.bibliographicCitationInternational Journal of Molecular Sciences, Vol.24 No.19-
dc.identifier.doi2-s2.0-85174675993-
dc.identifier.pmid37834109-
dc.identifier.scopusid2-s2.0-85174675993-
dc.identifier.urlhttp://www.mdpi.com/journal/ijms-
dc.subject.keywordanhydrous alum-
dc.subject.keywordCREB-
dc.subject.keywordERK-
dc.subject.keywordmelanogenesis-
dc.subject.keywordMITF-
dc.type.otherArticle-
dc.identifier.pissn1661-6596-
dc.description.isoatrue-
dc.subject.subareaCatalysis-
dc.subject.subareaMolecular Biology-
dc.subject.subareaSpectroscopy-
dc.subject.subareaComputer Science Applications-
dc.subject.subareaPhysical and Theoretical Chemistry-
dc.subject.subareaOrganic Chemistry-
dc.subject.subareaInorganic Chemistry-
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