Citation Export
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyeongmi | - |
dc.contributor.author | Yoon, Siyeoung | - |
dc.contributor.author | Choi, Junwon | - |
dc.contributor.author | Lee, Soonchul | - |
dc.date.issued | 2022-12-01 | - |
dc.identifier.issn | 1648-9144 | - |
dc.identifier.uri | https://aurora.ajou.ac.kr/handle/2018.oak/33144 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85144498671&origin=inward | - |
dc.description.abstract | Background and Objectives: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to control pain and fever. However, their effect on COVID-19 infected patients has not been fully studied. In this study, we investigated the effect of the duration of NSAIDs use on COVID-19 infection and clinical outcomes. Materials and Methods: In South Korea, 25,739 eligible patients who received COVID-19 testing between 1 January and 31 July 2020, were included in this retrospective observational cohort analysis. Based on the date of the first COVID-19 test for each patient, NSAID prescription dates were used to separate patients into two groups (short-term group: <2 weeks; long-term group: 8–12 weeks). COVID-19 infectivity and clinical outcomes were analyzed. We used the propensity score-matching (PSM) method. Results: Of the 580 patients who had taken NSAIDs before the date of COVID-19 test, 534 and 46 patients were grouped in the short- and long-term NSAID-use groups, respectively. We did not find a statistically significant increased risk of COVID-19 infection (adjustment for age and sex, p = 0.413; adjustment for age, sex, region of residence, comorbidity, Charlson Comorbidity Index, and current use of medication, p = 0.259) or change in clinical outcomes, including conventional oxygen therapy, admission of intensive care unit, artificial ventilation, or death, between the two groups in which the PSM method was applied. Conclusions: The duration of NSAIDs use did not have a statistically significant effect on COVID-19 infectivity or clinical outcomes. However, further studies looking at clinical presentation and laboratory test results in a large number of people should be performed. | - |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (Nos. 2022R1A2C2005916 and 2021R1G1A109434111). | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.subject.mesh | Anti-Inflammatory Agents, Non-Steroidal | - |
dc.subject.mesh | Cohort Studies | - |
dc.subject.mesh | COVID-19 | - |
dc.subject.mesh | COVID-19 Testing | - |
dc.subject.mesh | Humans | - |
dc.subject.mesh | Retrospective Studies | - |
dc.title | Effect of the Duration of NSAID Use on COVID-19 | - |
dc.type | Article | - |
dc.citation.number | 12 | - |
dc.citation.title | Medicina (Lithuania) | - |
dc.citation.volume | 58 | - |
dc.identifier.bibliographicCitation | Medicina (Lithuania), Vol.58 No.12 | - |
dc.identifier.doi | 10.3390/medicina58121713 | - |
dc.identifier.pmid | 36556916 | - |
dc.identifier.scopusid | 2-s2.0-85144498671 | - |
dc.identifier.url | https://www.mdpi.com/journal/medicina | - |
dc.subject.keyword | COVID-19 | - |
dc.subject.keyword | duration | - |
dc.subject.keyword | NSAID | - |
dc.type.other | Article | - |
dc.identifier.pissn | 1010-660X | - |
dc.description.isoa | true | - |
dc.subject.subarea | Medicine (all) | - |
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