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Effect of the Duration of NSAID Use on COVID-19oa mark
  • Kim, Kyeongmi ;
  • Yoon, Siyeoung ;
  • Choi, Junwon ;
  • Lee, Soonchul
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dc.contributor.authorKim, Kyeongmi-
dc.contributor.authorYoon, Siyeoung-
dc.contributor.authorChoi, Junwon-
dc.contributor.authorLee, Soonchul-
dc.date.issued2022-12-01-
dc.identifier.issn1648-9144-
dc.identifier.urihttps://aurora.ajou.ac.kr/handle/2018.oak/33144-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85144498671&origin=inward-
dc.description.abstractBackground and Objectives: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to control pain and fever. However, their effect on COVID-19 infected patients has not been fully studied. In this study, we investigated the effect of the duration of NSAIDs use on COVID-19 infection and clinical outcomes. Materials and Methods: In South Korea, 25,739 eligible patients who received COVID-19 testing between 1 January and 31 July 2020, were included in this retrospective observational cohort analysis. Based on the date of the first COVID-19 test for each patient, NSAID prescription dates were used to separate patients into two groups (short-term group: <2 weeks; long-term group: 8–12 weeks). COVID-19 infectivity and clinical outcomes were analyzed. We used the propensity score-matching (PSM) method. Results: Of the 580 patients who had taken NSAIDs before the date of COVID-19 test, 534 and 46 patients were grouped in the short- and long-term NSAID-use groups, respectively. We did not find a statistically significant increased risk of COVID-19 infection (adjustment for age and sex, p = 0.413; adjustment for age, sex, region of residence, comorbidity, Charlson Comorbidity Index, and current use of medication, p = 0.259) or change in clinical outcomes, including conventional oxygen therapy, admission of intensive care unit, artificial ventilation, or death, between the two groups in which the PSM method was applied. Conclusions: The duration of NSAIDs use did not have a statistically significant effect on COVID-19 infectivity or clinical outcomes. However, further studies looking at clinical presentation and laboratory test results in a large number of people should be performed.-
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (Nos. 2022R1A2C2005916 and 2021R1G1A109434111).-
dc.language.isoeng-
dc.publisherMDPI-
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal-
dc.subject.meshCohort Studies-
dc.subject.meshCOVID-19-
dc.subject.meshCOVID-19 Testing-
dc.subject.meshHumans-
dc.subject.meshRetrospective Studies-
dc.titleEffect of the Duration of NSAID Use on COVID-19-
dc.typeArticle-
dc.citation.number12-
dc.citation.titleMedicina (Lithuania)-
dc.citation.volume58-
dc.identifier.bibliographicCitationMedicina (Lithuania), Vol.58 No.12-
dc.identifier.doi10.3390/medicina58121713-
dc.identifier.pmid36556916-
dc.identifier.scopusid2-s2.0-85144498671-
dc.identifier.urlhttps://www.mdpi.com/journal/medicina-
dc.subject.keywordCOVID-19-
dc.subject.keywordduration-
dc.subject.keywordNSAID-
dc.type.otherArticle-
dc.identifier.pissn1010-660X-
dc.description.isoatrue-
dc.subject.subareaMedicine (all)-
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