Citation Export
DC Field | Value | Language |
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dc.contributor.author | Son, Ji Young | - |
dc.contributor.author | Kwack, Won Gun | - |
dc.contributor.author | Chung, Eun Kyoung | - |
dc.contributor.author | Shin, Sooyoung | - |
dc.contributor.author | Choi, Yeo Jin | - |
dc.date.issued | 2022-07-01 | - |
dc.identifier.issn | 2227-9032 | - |
dc.identifier.uri | https://aurora.ajou.ac.kr/handle/2018.oak/32803 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85133956574&origin=inward | - |
dc.description.abstract | This study aims to explore the effects of early dexamethasone therapy at low to high doses on the survival and inflammatory responses in lipopolysaccharide (LPS)-challenged mice. We performed two-series experiments to explore the impact of early dexamethasone therapy at different doses (0.5 mg/kg, 1.5 mg/kg, and 5 mg/kg; PO) on pro-inflammatory cytokine levels, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), as well as survival in LPS-treated mice (10 mg/kg, IP). Dexamethasone was administered daily from 24 h before and 5 days after LPS challenge. Dose-dependent improved survival was demonstrated with dexamethasone (p < 0.05). Body weight was significantly decreased within 24 h of LPS injection, with significantly greater weight loss in the dexamethasone groups (p < 0.05). Weight changes were significantly associated with the days after LPS administration (p < 0.01), but not with the dexamethasone dose (p > 0.05). Mice treated with high-dose dexamethasone (5 mg/kg) had a significantly lowered serum TNF-α (134.41 ± 15.83 vs. 408.83 ± 18.32) and IL-6 (22.08 ± 4.34 vs. 91.27 ± 8.56) compared with those without dexamethasone. This study provides essential insights that the suppression of early-phase hyperactivation of pro-inflammatory activities through the early initiation of high-dose dexamethasone therapy increases sepsis-related prognosis. | - |
dc.description.sponsorship | Acknowledgments: This research was supported by a grant (no. 21153MFDS601-1) from the Ministry of Food and Drug Safety in 2021. This study was partially supported by a National Research Foundation of Korea (NRF) grant funded by the Ministry of Education in Korea (2021R1I1A1A01044500) and by the Ministry of Science and ICT (2021R1C1C1003735). | - |
dc.description.sponsorship | Funding: This research was supported by a grant (No. 21153MFDS601-1) from the Ministry of Food and Drug Safety in 2021. This study was partially supported by a National Research Foundation of Korea (NRF) grant funded by the Ministry of Education in Korea (2021R1I1A1A01044500) and by the Ministry of Science and ICT (2021R1C1C1003735). | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.title | Effects of Early Initiation of High-Dose Dexamethasone Therapy on Pro-Inflammatory Cytokines and Mortality in LPS-Challenged Mice | - |
dc.type | Article | - |
dc.citation.number | 7 | - |
dc.citation.title | Healthcare (Switzerland) | - |
dc.citation.volume | 10 | - |
dc.identifier.bibliographicCitation | Healthcare (Switzerland), Vol.10 No.7 | - |
dc.identifier.doi | 2-s2.0-85133956574 | - |
dc.identifier.scopusid | 2-s2.0-85133956574 | - |
dc.identifier.url | https://www.mdpi.com/2227-9032/10/7/1247/pdf?version=1656942967 | - |
dc.subject.keyword | acute inflammation | - |
dc.subject.keyword | corticosteroid | - |
dc.subject.keyword | dexamethasone | - |
dc.subject.keyword | lipopolysaccharide | - |
dc.subject.keyword | sepsis | - |
dc.type.other | Article | - |
dc.description.isoa | true | - |
dc.subject.subarea | Leadership and Management | - |
dc.subject.subarea | Health Policy | - |
dc.subject.subarea | Health Informatics | - |
dc.subject.subarea | Health Information Management | - |
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