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Effects of Early Initiation of High-Dose Dexamethasone Therapy on Pro-Inflammatory Cytokines and Mortality in LPS-Challenged Miceoa mark
  • Son, Ji Young ;
  • Kwack, Won Gun ;
  • Chung, Eun Kyoung ;
  • Shin, Sooyoung ;
  • Choi, Yeo Jin
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dc.contributor.authorSon, Ji Young-
dc.contributor.authorKwack, Won Gun-
dc.contributor.authorChung, Eun Kyoung-
dc.contributor.authorShin, Sooyoung-
dc.contributor.authorChoi, Yeo Jin-
dc.date.issued2022-07-01-
dc.identifier.issn2227-9032-
dc.identifier.urihttps://aurora.ajou.ac.kr/handle/2018.oak/32803-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85133956574&origin=inward-
dc.description.abstractThis study aims to explore the effects of early dexamethasone therapy at low to high doses on the survival and inflammatory responses in lipopolysaccharide (LPS)-challenged mice. We performed two-series experiments to explore the impact of early dexamethasone therapy at different doses (0.5 mg/kg, 1.5 mg/kg, and 5 mg/kg; PO) on pro-inflammatory cytokine levels, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), as well as survival in LPS-treated mice (10 mg/kg, IP). Dexamethasone was administered daily from 24 h before and 5 days after LPS challenge. Dose-dependent improved survival was demonstrated with dexamethasone (p < 0.05). Body weight was significantly decreased within 24 h of LPS injection, with significantly greater weight loss in the dexamethasone groups (p < 0.05). Weight changes were significantly associated with the days after LPS administration (p < 0.01), but not with the dexamethasone dose (p > 0.05). Mice treated with high-dose dexamethasone (5 mg/kg) had a significantly lowered serum TNF-α (134.41 ± 15.83 vs. 408.83 ± 18.32) and IL-6 (22.08 ± 4.34 vs. 91.27 ± 8.56) compared with those without dexamethasone. This study provides essential insights that the suppression of early-phase hyperactivation of pro-inflammatory activities through the early initiation of high-dose dexamethasone therapy increases sepsis-related prognosis.-
dc.description.sponsorshipAcknowledgments: This research was supported by a grant (no. 21153MFDS601-1) from the Ministry of Food and Drug Safety in 2021. This study was partially supported by a National Research Foundation of Korea (NRF) grant funded by the Ministry of Education in Korea (2021R1I1A1A01044500) and by the Ministry of Science and ICT (2021R1C1C1003735).-
dc.description.sponsorshipFunding: This research was supported by a grant (No. 21153MFDS601-1) from the Ministry of Food and Drug Safety in 2021. This study was partially supported by a National Research Foundation of Korea (NRF) grant funded by the Ministry of Education in Korea (2021R1I1A1A01044500) and by the Ministry of Science and ICT (2021R1C1C1003735).-
dc.language.isoeng-
dc.publisherMDPI-
dc.titleEffects of Early Initiation of High-Dose Dexamethasone Therapy on Pro-Inflammatory Cytokines and Mortality in LPS-Challenged Mice-
dc.typeArticle-
dc.citation.number7-
dc.citation.titleHealthcare (Switzerland)-
dc.citation.volume10-
dc.identifier.bibliographicCitationHealthcare (Switzerland), Vol.10 No.7-
dc.identifier.doi2-s2.0-85133956574-
dc.identifier.scopusid2-s2.0-85133956574-
dc.identifier.urlhttps://www.mdpi.com/2227-9032/10/7/1247/pdf?version=1656942967-
dc.subject.keywordacute inflammation-
dc.subject.keywordcorticosteroid-
dc.subject.keyworddexamethasone-
dc.subject.keywordlipopolysaccharide-
dc.subject.keywordsepsis-
dc.type.otherArticle-
dc.description.isoatrue-
dc.subject.subareaLeadership and Management-
dc.subject.subareaHealth Policy-
dc.subject.subareaHealth Informatics-
dc.subject.subareaHealth Information Management-
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