Citation Export
DC Field | Value | Language |
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dc.contributor.author | Lee, Gwan Yeong | - |
dc.contributor.author | Zeb, Alam | - |
dc.contributor.author | Kim, Eun Hye | - |
dc.contributor.author | Suh, Beomseon | - |
dc.contributor.author | Shin, Young Jun | - |
dc.contributor.author | Kim, Donghyun | - |
dc.contributor.author | Kim, Kyoung Won | - |
dc.contributor.author | Choe, Yeong Hwan | - |
dc.contributor.author | Choi, Ho Ik | - |
dc.contributor.author | Lee, Cheol Ho | - |
dc.contributor.author | Qureshi, Omer Salman | - |
dc.contributor.author | Han, In Bo | - |
dc.contributor.author | Chang, Sun Young | - |
dc.contributor.author | Bae, Ok Nam | - |
dc.contributor.author | Kim, Jin Ki | - |
dc.date.issued | 2020-12-01 | - |
dc.identifier.issn | 2211-3843 | - |
dc.identifier.uri | https://aurora.ajou.ac.kr/handle/2018.oak/31638 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85094588327&origin=inward | - |
dc.description.abstract | The short release half-life of carbon monoxide (CO) is a major obstacle to the effective therapeutic use of carbon monoxide-releasing molecule-2 (CORM-2). The potential of CORM-2-entrapped ultradeformable liposomes (CORM-2-UDLs) to enhance the release half-life of CO and alleviate skin inflammation was investigated in the present study. CORM-2-UDLs were prepared by using soy phosphatidylcholine to form lipid bilayers and Tween 80 as an edge activator. The deformability of CORM-2-UDLs was measured and compared with that of conventional liposomes by passing formulations through a filter device at a constant pressure. The release profile of CO from CORM-2-UDLs was evaluated by myoglobin assay. In vitro and in vivo anti-inflammatory effects of CORM-2-UDLs were assessed in lipopolysaccharide-stimulated macrophages and TPA-induced ear edema model, respectively. The deformability of the optimized CORM-2-UDLs was 2.3 times higher than conventional liposomes. CORM-2-UDLs significantly prolonged the release half-life of CO from 30 s in a CORM-2 solution to 21.6 min. CORM-2-UDLs demonstrated in vitro anti-inflammatory activity by decreasing nitrite production and pro-inflammatory cytokine levels. Furthermore, CORM-2-UDLs successfully ameliorated skin inflammation by reducing ear edema, pathological scores, neutrophil accumulation, and inflammatory cytokines expression. The results demonstrate that CORM-2-UDLs could be used as promising therapeutics against acute skin inflammation. | - |
dc.description.sponsorship | This work was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT ( NRF-2017R1A2B4006458 ). | - |
dc.description.sponsorship | This work was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017R1A2B4006458). | - |
dc.language.iso | eng | - |
dc.publisher | Chinese Academy of Medical Sciences | - |
dc.title | CORM-2-entrapped ultradeformable liposomes ameliorate acute skin inflammation in an ear edema model via effective CO delivery | - |
dc.type | Article | - |
dc.citation.endPage | 2373 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2362 | - |
dc.citation.title | Acta Pharmaceutica Sinica B | - |
dc.citation.volume | 10 | - |
dc.identifier.bibliographicCitation | Acta Pharmaceutica Sinica B, Vol.10 No.12, pp.2362-2373 | - |
dc.identifier.doi | 2-s2.0-85094588327 | - |
dc.identifier.scopusid | 2-s2.0-85094588327 | - |
dc.identifier.url | http://www.elsevier.com/wps/find/journaldescription.cws_home/725753/description#description | - |
dc.subject.keyword | Anti-inflammatory effect | - |
dc.subject.keyword | Carbon monoxide | - |
dc.subject.keyword | CORM-2 | - |
dc.subject.keyword | Ear edema | - |
dc.subject.keyword | Skin inflammation | - |
dc.subject.keyword | Ultradeformable liposomes | - |
dc.type.other | Article | - |
dc.identifier.pissn | 2211-3835 | - |
dc.description.isoa | true | - |
dc.subject.subarea | Pharmacology, Toxicology and Pharmaceutics (all) | - |
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