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CORM-2-entrapped ultradeformable liposomes ameliorate acute skin inflammation in an ear edema model via effective CO deliveryoa mark
  • Lee, Gwan Yeong ;
  • Zeb, Alam ;
  • Kim, Eun Hye ;
  • Suh, Beomseon ;
  • Shin, Young Jun ;
  • Kim, Donghyun ;
  • Kim, Kyoung Won ;
  • Choe, Yeong Hwan ;
  • Choi, Ho Ik ;
  • Lee, Cheol Ho ;
  • Qureshi, Omer Salman ;
  • Han, In Bo ;
  • Chang, Sun Young ;
  • Bae, Ok Nam ;
  • Kim, Jin Ki
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dc.contributor.authorLee, Gwan Yeong-
dc.contributor.authorZeb, Alam-
dc.contributor.authorKim, Eun Hye-
dc.contributor.authorSuh, Beomseon-
dc.contributor.authorShin, Young Jun-
dc.contributor.authorKim, Donghyun-
dc.contributor.authorKim, Kyoung Won-
dc.contributor.authorChoe, Yeong Hwan-
dc.contributor.authorChoi, Ho Ik-
dc.contributor.authorLee, Cheol Ho-
dc.contributor.authorQureshi, Omer Salman-
dc.contributor.authorHan, In Bo-
dc.contributor.authorChang, Sun Young-
dc.contributor.authorBae, Ok Nam-
dc.contributor.authorKim, Jin Ki-
dc.date.issued2020-12-01-
dc.identifier.issn2211-3843-
dc.identifier.urihttps://aurora.ajou.ac.kr/handle/2018.oak/31638-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85094588327&origin=inward-
dc.description.abstractThe short release half-life of carbon monoxide (CO) is a major obstacle to the effective therapeutic use of carbon monoxide-releasing molecule-2 (CORM-2). The potential of CORM-2-entrapped ultradeformable liposomes (CORM-2-UDLs) to enhance the release half-life of CO and alleviate skin inflammation was investigated in the present study. CORM-2-UDLs were prepared by using soy phosphatidylcholine to form lipid bilayers and Tween 80 as an edge activator. The deformability of CORM-2-UDLs was measured and compared with that of conventional liposomes by passing formulations through a filter device at a constant pressure. The release profile of CO from CORM-2-UDLs was evaluated by myoglobin assay. In vitro and in vivo anti-inflammatory effects of CORM-2-UDLs were assessed in lipopolysaccharide-stimulated macrophages and TPA-induced ear edema model, respectively. The deformability of the optimized CORM-2-UDLs was 2.3 times higher than conventional liposomes. CORM-2-UDLs significantly prolonged the release half-life of CO from 30 s in a CORM-2 solution to 21.6 min. CORM-2-UDLs demonstrated in vitro anti-inflammatory activity by decreasing nitrite production and pro-inflammatory cytokine levels. Furthermore, CORM-2-UDLs successfully ameliorated skin inflammation by reducing ear edema, pathological scores, neutrophil accumulation, and inflammatory cytokines expression. The results demonstrate that CORM-2-UDLs could be used as promising therapeutics against acute skin inflammation.-
dc.description.sponsorshipThis work was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT ( NRF-2017R1A2B4006458 ).-
dc.description.sponsorshipThis work was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017R1A2B4006458).-
dc.language.isoeng-
dc.publisherChinese Academy of Medical Sciences-
dc.titleCORM-2-entrapped ultradeformable liposomes ameliorate acute skin inflammation in an ear edema model via effective CO delivery-
dc.typeArticle-
dc.citation.endPage2373-
dc.citation.number12-
dc.citation.startPage2362-
dc.citation.titleActa Pharmaceutica Sinica B-
dc.citation.volume10-
dc.identifier.bibliographicCitationActa Pharmaceutica Sinica B, Vol.10 No.12, pp.2362-2373-
dc.identifier.doi2-s2.0-85094588327-
dc.identifier.scopusid2-s2.0-85094588327-
dc.identifier.urlhttp://www.elsevier.com/wps/find/journaldescription.cws_home/725753/description#description-
dc.subject.keywordAnti-inflammatory effect-
dc.subject.keywordCarbon monoxide-
dc.subject.keywordCORM-2-
dc.subject.keywordEar edema-
dc.subject.keywordSkin inflammation-
dc.subject.keywordUltradeformable liposomes-
dc.type.otherArticle-
dc.identifier.pissn2211-3835-
dc.description.isoatrue-
dc.subject.subareaPharmacology, Toxicology and Pharmaceutics (all)-
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