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Development of film-forming gel containing nanoparticles for transdermal drug delivery
  • Ngo, Hai V. ;
  • Tran, Phuong H.L. ;
  • Lee, Beom Jin ;
  • Tran, Thao T.D.
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dc.contributor.authorNgo, Hai V.-
dc.contributor.authorTran, Phuong H.L.-
dc.contributor.authorLee, Beom Jin-
dc.contributor.authorTran, Thao T.D.-
dc.date.issued2019-07-25-
dc.identifier.issn1361-6528-
dc.identifier.urihttps://aurora.ajou.ac.kr/handle/2018.oak/30893-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071449087&origin=inward-
dc.description.abstractDespite several studies on film-forming systems with the advantages of both the film and the hydrogel, there are still no effective systems for fast film formation with a high level of control over permeability. In this study, a film-forming system for the delivery of nanomedicine, termed a film-forming nanogel (FFN), was produced and investigated for the first time to meet this need. The objective of this research was to study a new generation of film-forming hydrogels (FFHs) loaded with curcumin nanoparticles (CUR-GNPs) for transdermal applications. FFHs were prepared by employing zein and HPMC 4000 as film-forming polymers. Meanwhile, CUR-GNPs were obtained by sonoprecipitation. The film-forming time, particle characteristics and FFN drug release profile were assessed. The optimized FFH had a smooth surface and a fast drying time of 6 min and 4.5 min in vitro and ex vivo, respectively. Additionally, high, sustained drug permeation from the FFN was observed after 24 h. The FFH containing CUR-GNPs showed potential for application in transdermal drug delivery with a fast film-forming time, uniform particle dispersion and high, sustained drug permeation.-
dc.language.isoeng-
dc.publisherInstitute of Physics Publishing-
dc.subject.meshEffective systems-
dc.subject.meshFilm-forming-
dc.subject.meshGelatin nanoparticles-
dc.subject.meshNanogels-
dc.subject.meshParticle characteristics-
dc.subject.meshParticle dispersion-
dc.subject.meshsonoprecipitation-
dc.subject.meshTransdermal drug delivery-
dc.subject.meshAdministration, Cutaneous-
dc.subject.meshAnimals-
dc.subject.meshCurcumin-
dc.subject.meshDrug Carriers-
dc.subject.meshDrug Delivery Systems-
dc.subject.meshDrug Liberation-
dc.subject.meshHydrogels-
dc.subject.meshMethylgalactosides-
dc.subject.meshNanoparticles-
dc.subject.meshParticle Size-
dc.subject.meshPermeability-
dc.subject.meshPolymers-
dc.subject.meshSkin-
dc.subject.meshSkin Absorption-
dc.subject.meshSolubility-
dc.subject.meshSwine-
dc.titleDevelopment of film-forming gel containing nanoparticles for transdermal drug delivery-
dc.typeArticle-
dc.citation.number41-
dc.citation.titleNanotechnology-
dc.citation.volume30-
dc.identifier.bibliographicCitationNanotechnology, Vol.30 No.41-
dc.identifier.doi10.1088/1361-6528/ab2e29-
dc.identifier.pmid31261146-
dc.identifier.scopusid2-s2.0-85071449087-
dc.identifier.urlhttps://iopscience.iop.org/article/10.1088/1361-6528/ab2e29/pdf-
dc.subject.keywordfilm-forming hydrogel-
dc.subject.keywordgelatin nanoparticles-
dc.subject.keywordnanogel-
dc.subject.keywordsonoprecipitation-
dc.subject.keywordzein/HPMC-
dc.type.otherArticle-
dc.identifier.pissn0957-4484-
dc.description.isoafalse-
dc.subject.subareaBioengineering-
dc.subject.subareaChemistry (all)-
dc.subject.subareaMaterials Science (all)-
dc.subject.subareaMechanics of Materials-
dc.subject.subareaMechanical Engineering-
dc.subject.subareaElectrical and Electronic Engineering-
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