Citation Export
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ngo, Hai V. | - |
dc.contributor.author | Tran, Phuong H.L. | - |
dc.contributor.author | Lee, Beom Jin | - |
dc.contributor.author | Tran, Thao T.D. | - |
dc.date.issued | 2019-07-25 | - |
dc.identifier.issn | 1361-6528 | - |
dc.identifier.uri | https://aurora.ajou.ac.kr/handle/2018.oak/30893 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071449087&origin=inward | - |
dc.description.abstract | Despite several studies on film-forming systems with the advantages of both the film and the hydrogel, there are still no effective systems for fast film formation with a high level of control over permeability. In this study, a film-forming system for the delivery of nanomedicine, termed a film-forming nanogel (FFN), was produced and investigated for the first time to meet this need. The objective of this research was to study a new generation of film-forming hydrogels (FFHs) loaded with curcumin nanoparticles (CUR-GNPs) for transdermal applications. FFHs were prepared by employing zein and HPMC 4000 as film-forming polymers. Meanwhile, CUR-GNPs were obtained by sonoprecipitation. The film-forming time, particle characteristics and FFN drug release profile were assessed. The optimized FFH had a smooth surface and a fast drying time of 6 min and 4.5 min in vitro and ex vivo, respectively. Additionally, high, sustained drug permeation from the FFN was observed after 24 h. The FFH containing CUR-GNPs showed potential for application in transdermal drug delivery with a fast film-forming time, uniform particle dispersion and high, sustained drug permeation. | - |
dc.language.iso | eng | - |
dc.publisher | Institute of Physics Publishing | - |
dc.subject.mesh | Effective systems | - |
dc.subject.mesh | Film-forming | - |
dc.subject.mesh | Gelatin nanoparticles | - |
dc.subject.mesh | Nanogels | - |
dc.subject.mesh | Particle characteristics | - |
dc.subject.mesh | Particle dispersion | - |
dc.subject.mesh | sonoprecipitation | - |
dc.subject.mesh | Transdermal drug delivery | - |
dc.subject.mesh | Administration, Cutaneous | - |
dc.subject.mesh | Animals | - |
dc.subject.mesh | Curcumin | - |
dc.subject.mesh | Drug Carriers | - |
dc.subject.mesh | Drug Delivery Systems | - |
dc.subject.mesh | Drug Liberation | - |
dc.subject.mesh | Hydrogels | - |
dc.subject.mesh | Methylgalactosides | - |
dc.subject.mesh | Nanoparticles | - |
dc.subject.mesh | Particle Size | - |
dc.subject.mesh | Permeability | - |
dc.subject.mesh | Polymers | - |
dc.subject.mesh | Skin | - |
dc.subject.mesh | Skin Absorption | - |
dc.subject.mesh | Solubility | - |
dc.subject.mesh | Swine | - |
dc.title | Development of film-forming gel containing nanoparticles for transdermal drug delivery | - |
dc.type | Article | - |
dc.citation.number | 41 | - |
dc.citation.title | Nanotechnology | - |
dc.citation.volume | 30 | - |
dc.identifier.bibliographicCitation | Nanotechnology, Vol.30 No.41 | - |
dc.identifier.doi | 10.1088/1361-6528/ab2e29 | - |
dc.identifier.pmid | 31261146 | - |
dc.identifier.scopusid | 2-s2.0-85071449087 | - |
dc.identifier.url | https://iopscience.iop.org/article/10.1088/1361-6528/ab2e29/pdf | - |
dc.subject.keyword | film-forming hydrogel | - |
dc.subject.keyword | gelatin nanoparticles | - |
dc.subject.keyword | nanogel | - |
dc.subject.keyword | sonoprecipitation | - |
dc.subject.keyword | zein/HPMC | - |
dc.type.other | Article | - |
dc.identifier.pissn | 0957-4484 | - |
dc.description.isoa | false | - |
dc.subject.subarea | Bioengineering | - |
dc.subject.subarea | Chemistry (all) | - |
dc.subject.subarea | Materials Science (all) | - |
dc.subject.subarea | Mechanics of Materials | - |
dc.subject.subarea | Mechanical Engineering | - |
dc.subject.subarea | Electrical and Electronic Engineering | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.