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Three-Component Annulation of Arynes with Phosphites and Ketones
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 최준원 | - |
| dc.contributor.author | 김지호 | - |
| dc.date.accessioned | 2025-01-25T01:35:56Z | - |
| dc.date.available | 2025-01-25T01:35:56Z | - |
| dc.date.issued | 2023-02 | - |
| dc.identifier.other | 32783 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/24398 | - |
| dc.description | 학위논문(석사)--분자과학기술학과,2023. 2 | - |
| dc.description.tableofcontents | 1. Introduction 1 <br>2. Result and Discussion 3 <br> 2.1. Reaction Optimization 3 <br> 2.2. Substrates Scope 5 <br> 2.3. Mechanistic Study 11 <br> 2.4. Application 13 <br>3.Conclusion 15 <br>4. Experimental Procedure 16 <br> 4.1. General Information 16 <br> 4.2. Synthetic Procedure 17 <br>5. Reference 73 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | Three-Component Annulation of Arynes with Phosphites and Ketones | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 대학원 | - |
| dc.contributor.alternativeName | Jiho Kim | - |
| dc.contributor.department | 일반대학원 분자과학기술학과 | - |
| dc.date.awarded | 2023-02 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | T000000032783 | - |
| dc.identifier.url | https://dcoll.ajou.ac.kr/dcollection/common/orgView/000000032783 | - |
| dc.subject.keyword | 유기화학 | - |
| dc.description.alternativeAbstract | A mild and transition-metal-free three-component annulation was performed to obtain benzoxaphosphole 1-oxides using in situ formed arynes. We employed readily available substrates, 2-(trimethylsilyl)aryl triflates, phosphites, and ketones, as the three components; substrates with various functional groups, including the non-activated ketones, could be tolerated. The mechanistic study revealed that the pentavalent phosphorus intermediate might be produced through a three-component annulation and then converted to benzoxaphosphole 1-oxides, the desired compound, by hydrolysis in an aqueous workup step. Furthermore, we investigated the potential applications of this reaction by derivatizing the produced benzoxaphosphole 1-oxides. Our results improved the approaches to preparing organophosphorus compounds used in pharmaceuticals, materials, and natural products. | - |
| dc.title.subtitle | Synthesis of Benzoxaphosphole 1-Oxides | - |
- Appears in Collections:
- Graduate School of Ajou University > Department of Molecular Science and Technology > 3. Theses(Master)
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