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Serum 25-hydroxyvitamin D3 is associated with homocysteine more than with apolipoprotein B100
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 주남석 | - |
| dc.contributor.author | 김남규 | - |
| dc.date.accessioned | 2025-01-25T01:35:53Z | - |
| dc.date.available | 2025-01-25T01:35:53Z | - |
| dc.date.issued | 2023-02 | - |
| dc.identifier.other | 32558 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/24347 | - |
| dc.description | 학위논문(박사)--아주대학교 일반대학원 :의학과,2023. 2 | - |
| dc.description.tableofcontents | I. Introduction 1 <br>II. Subjects and methods 3 <br> A. Data resources 3 <br> B. Anthropometric measurements and laboratory data 3 <br> C. Statistical analysis 4 <br>III. Results 5 <br> A. Participant characteristics 5 <br> B. Associations of serum 25(OH)D with serum homocysteine and ApoB100 5 <br>IV. Discussion 6 <br>V. List of Tables 9 <br>VI. References 15 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | Serum 25-hydroxyvitamin D3 is associated with homocysteine more than with apolipoprotein B100 | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 대학원 | - |
| dc.contributor.department | 일반대학원 의학과 | - |
| dc.date.awarded | 2023-02 | - |
| dc.description.degree | Doctor | - |
| dc.identifier.localId | T000000032558 | - |
| dc.identifier.url | https://dcoll.ajou.ac.kr/dcollection/common/orgView/000000032558 | - |
| dc.subject.keyword | 25-hydroxyvitamin D3 | - |
| dc.subject.keyword | Apolipoprotein B100 | - |
| dc.subject.keyword | Cardiovascular diseases | - |
| dc.subject.keyword | Homocysteine | - |
| dc.description.alternativeAbstract | Background and objectives: The incidence of cardiovascular diseases (CVDs) has increased worldwide. Although a low serum vitamin D level is known to be associated with the risk of CVD, the mechanism is not well understood yet. The aim of this study was to determine the relationship of serum 25-hydroxyvitamin D3 [25(OH)D] with homocysteine and apolipoprotein B100 (ApoB100). <br> <br>Subjects and methods: Of 777 subjects recruited from one health promotion center for routine heath exam from January 2010 to December 2016, 518 subjects were included in this study. Serum 25(OH)D, serum homocysteine, and other metabolic parameters including ApoB100 were analyzed. Simple and partial correlations were carried out after adjustments. Simple linear regression analysis was used for precise correlation of parameters. Multivariate regression analysis was done to know which factor (serum homocysteine or ApoB100) was more related to serum 25(OH)D after adjustments. Finally, logarithms of homocysteine concentrations according to tertiles of serum 25(OH)D were compared. <br> <br>Results: After sex and age adjustments, serum 25(OH)D showed negative correlations with serum homocysteine (r’ = −0.114) and ApoB100 (r’ = −0.098). In simple linear regression analysis, serum 25(OH)D showed a significant negative correlation with ApoB100 (P = 0.035). However, in multivariate regression analysis, serum 25(OH)D was significantly associated with serum homocysteine after adjustments (P = 0.022). In addition, serum homocysteine concentration was significantly high in the lowest 25(OH)D group (P = 0.046). <br> <br>Conclusion: Serum 25(OH)D concentration showed a stronger negative association with serum homocysteine than with ApoB100. | - |
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- Graduate School of Ajou University > Department of Medicine > 4. Theses(Ph.D)
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