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The value of drain fluid amylase as a predictor of postoperative pancreatic fistula after pancreaticogastrostomy
- Author(s)
- YUAN SHUAI
- Alternative Author(s)
- YUAN SHUAI
- Advisor
- Ji Hun Kim
- Department
- 일반대학원 의학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2023-02
- Language
- eng
- Keyword
- Pancreaticoduodenectomy; drain fluid amylase; pancreatic fistula; pancreaticogastrostomy; relevant postoperative pancreatic fistula
- Alternative Abstract
- Background/Aim: Drain fluid amylase is commonly used as a predictor of pancreatic fistula after pancreaticoduodenectomy (PD). This study aimed to determine the ideal cut-off value of drain fluid amylase on postoperative day 1 (DFA1) for predicting pancreatic fistula after pancreaticogastrostomy (PG). <br>Patients and Methods: Prospective data of 272 consecutive patients undergoing PG between 2010 and 2020 was collected and analyzed to determine the postoperative pancreatic fistula (POPF) risk factors. <br>Results: The incidence of POPF was 143 cases (52.6%). The median DFA1 in patients with POPF was significantly higher than that of patients with NO-POPF (5483 vs 311, P < 0.001). DFA1 correlated with POPF in the area under the curve (AUC) of 0.84 (P < 0.001). When DFA1 was 2300U/L, Youden index was the highest, with a sensitivity of 72.7% and a specificity of 82.9%. Logistic regression analysis showed that DFA1≥2300U/L was an independent predictor of POPF (P < 0.001; OR: 12.855; 95% CI: 7.019-23.544). The AUC of DFA1 and clinically relevant postoperative pancreatic fistula (CR-POPF) was 0.674 (P < 0.001). <br>Conclusion: DFA1≥2300U/L can be used as an independent predictor of POPF after PG. DFA1≥3000U/L can predict the occurrence of CR-POPF, when DFA1≥3000U/L, the patients should be observed closely active for complications.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Medicine > 4. Theses(Ph.D)
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