In this study, oil-in-water nanoemulsions are prepared, an isotropic mixture of oil, surfactant, and cosurfactants. The nanoemulsions exhibit stable structures and are capable of efficiently encapsulating hydrophobic drugs such as doxorubicin (Dox). Compared to polymeric micelles, nanoemulsions demonstrate enhanced stability and loading capacity for Dox. Furthermore, nanoemulsions release Dox steadily over 14 days, with 51.6% released within the initial 24 h and up to 80% over the subsequent period. These properties suggest that nanoemulsions can mitigate the side effects related to the burst release of Dox, thereby improving therapeutic efficacy and safety. Additionally, nanoemulsion-treated cardiomyocytes show increased viability compared to those treated with free Dox, indicating the potential of nanoemulsions to alleviate Dox-induced cardiotoxicity. Overall, nanoemulsions hold promise as versatile and efficient drug carriers for improving cancer treatment outcomes.
This research was supported by the programs through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2020R1A2C1010766 and RS-2023-00281553) and by the Ministry of Education (NRF-2022R1A5A8023404 and RS-2023-00241311). This work was supported by the Global Joint Research Program funded by the Pukyong National University. The authors acknowledge Grammarly software in enhancing the clarity and correctness of language.This research was supported by the programs through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF\u20102020R1A2C1010766 and RS\u20102023\u201000281553) and by the Ministry of Education (NRF\u20102022R1A5A8023404 and RS\u20102023\u201000241311). This work was supported by the Global Joint Research Program funded by the Pukyong National University. The authors acknowledge Grammarly software in enhancing the clarity and correctness of language.
