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A red-emissive two-photon fluorescent probe for mitochondrial sodium ions in live tissue
  • Juvekar, Vinayak ;
  • Cho, Myoung Ki ;
  • Lee, Hyo Won ;
  • Lee, Dong Joon ;
  • Kang, Hyuk ;
  • Song, Ju Man ;
  • Je, Jong Tae ;
  • Kim, Hwan Myung
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dc.contributor.authorJuvekar, Vinayak-
dc.contributor.authorCho, Myoung Ki-
dc.contributor.authorLee, Hyo Won-
dc.contributor.authorLee, Dong Joon-
dc.contributor.authorKang, Hyuk-
dc.contributor.authorSong, Ju Man-
dc.contributor.authorJe, Jong Tae-
dc.contributor.authorKim, Hwan Myung-
dc.date.issued2021-09-14-
dc.identifier.urihttps://dspace.ajou.ac.kr/dev/handle/2018.oak/32250-
dc.description.abstractA cyclocyanine (CC)-based organic small molecule two-photon (TP) fluorescent probe (CCNa1) was developed for mitochondrial sodium ion sensing.CCNa1exhibits a low solvatochromic shift and strong TP fluorescence enhancement at 575 nm upon binding to Na+and is insensitive to other metal ions and to pH.CCNa1demonstrated fast cell loading ability, biocompatibility, and sensitive response to mitochondrial Na+influx in live cells and mouse brain tissue.-
dc.description.sponsorshipThis study was supported by grants from the Advanced Technology Center (ATC) Program (10076988) funded by the Ministry of Trade, Industry & Energy, and the National Leading Research Lab Program of the National Research Foundation of Korea (NRF) (NRF-2019R1A2B5B03100278), and Center for Convergence Research of Neurological Disorders (NRF-2019R1A5A2026045).-
dc.language.isoeng-
dc.publisherRoyal Society of Chemistry-
dc.subject.meshCell loading-
dc.subject.meshFluorescence enhancement-
dc.subject.meshFluorescent probes-
dc.subject.meshLive tissue-
dc.subject.meshMouse brain-
dc.subject.meshOrganic small molecule-
dc.subject.meshRed emissive-
dc.subject.meshSolvatochromic shifts-
dc.subject.meshAnimals-
dc.subject.meshCrown Ethers-
dc.subject.meshFluorescent Dyes-
dc.subject.meshHeLa Cells-
dc.subject.meshHeterocyclic Compounds, 4 or More Rings-
dc.subject.meshHippocampus-
dc.subject.meshHumans-
dc.subject.meshMice-
dc.subject.meshMitochondria-
dc.subject.meshPhotons-
dc.subject.meshSodium-
dc.titleA red-emissive two-photon fluorescent probe for mitochondrial sodium ions in live tissue-
dc.typeArticle-
dc.citation.endPage8932-
dc.citation.startPage8929-
dc.citation.titleChemical Communications-
dc.citation.volume57-
dc.identifier.bibliographicCitationChemical Communications, Vol.57, pp.8929-8932-
dc.identifier.doi10.1039/d1cc03617c-
dc.identifier.pmid34397047-
dc.identifier.scopusid2-s2.0-85114331673-
dc.identifier.urlhttp://pubs.rsc.org/en/journals/journal/cc-
dc.description.isoafalse-
dc.subject.subareaElectronic, Optical and Magnetic Materials-
dc.subject.subareaCatalysis-
dc.subject.subareaCeramics and Composites-
dc.subject.subareaChemistry (all)-
dc.subject.subareaSurfaces, Coatings and Films-
dc.subject.subareaMetals and Alloys-
dc.subject.subareaMaterials Chemistry-
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