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Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer
  • Nguyen, Van Nghia ;
  • Park, Sang Jun ;
  • Qi, Sujie ;
  • Ha, Jeongsun ;
  • Heo, Seonye ;
  • Yim, Yubin ;
  • Baek, Gain ;
  • Lim, Chang Su ;
  • Lee, Dong Joon ;
  • Kim, Hwan Myung ;
  • Yoon, Juyoung
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dc.contributor.authorNguyen, Van Nghia-
dc.contributor.authorPark, Sang Jun-
dc.contributor.authorQi, Sujie-
dc.contributor.authorHa, Jeongsun-
dc.contributor.authorHeo, Seonye-
dc.contributor.authorYim, Yubin-
dc.contributor.authorBaek, Gain-
dc.contributor.authorLim, Chang Su-
dc.contributor.authorLee, Dong Joon-
dc.contributor.authorKim, Hwan Myung-
dc.contributor.authorYoon, Juyoung-
dc.date.issued2020-10-04-
dc.identifier.urihttps://dspace.ajou.ac.kr/dev/handle/2018.oak/31577-
dc.description.abstractNovel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.-
dc.description.sponsorshipThis study was supported by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814 for J. Y. and No. 2019R1A2B5B03100278 for H. M. K.).-
dc.language.isoeng-
dc.publisherRoyal Society of Chemistry-
dc.subject.meshHeavy atoms-
dc.subject.meshHeLa cell-
dc.subject.meshPhoto-toxicity-
dc.subject.meshRos generations-
dc.subject.meshThiocarbonyl-
dc.subject.meshTwo-photon excitations-
dc.subject.meshTwo-photon excited-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshCell Proliferation-
dc.subject.meshCell Survival-
dc.subject.meshDrug Design-
dc.subject.meshDrug Screening Assays, Antitumor-
dc.subject.meshHeLa Cells-
dc.subject.meshHumans-
dc.subject.meshMolecular Structure-
dc.subject.meshOptical Imaging-
dc.subject.meshPhotochemotherapy-
dc.subject.meshPhotosensitizing Agents-
dc.subject.meshSulfhydryl Compounds-
dc.titleDesign and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer-
dc.typeArticle-
dc.citation.endPage11492-
dc.citation.startPage11489-
dc.citation.titleChemical Communications-
dc.citation.volume56-
dc.identifier.bibliographicCitationChemical Communications, Vol.56, pp.11489-11492-
dc.identifier.doi10.1039/d0cc04644b-
dc.identifier.pmid32857074-
dc.identifier.scopusid2-s2.0-85091890742-
dc.identifier.urlhttp://pubs.rsc.org/en/journals/journal/cc-
dc.description.isoafalse-
dc.subject.subareaCatalysis-
dc.subject.subareaElectronic, Optical and Magnetic Materials-
dc.subject.subareaCeramics and Composites-
dc.subject.subareaChemistry (all)-
dc.subject.subareaSurfaces, Coatings and Films-
dc.subject.subareaMetals and Alloys-
dc.subject.subareaMaterials Chemistry-
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