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Azulene-Derived Fluorescent Probe for Bioimaging: Detection of Reactive Oxygen and Nitrogen Species by Two-Photon Microscopyoa mark
  • Murfin, Lloyd C. ;
  • Weber, Maria ;
  • Park, Sang Jun ;
  • Kim, Won Tae ;
  • Lopez-Alled, Carlos M. ;
  • McMullin, Claire L. ;
  • Pradaux-Caggiano, Fabienne ;
  • Lyall, Catherine L. ;
  • Kociok-Köhn, Gabriele ;
  • Wenk, Jannis ;
  • Bull, Steven D. ;
  • Yoon, Juyoung ;
  • Kim, Hwan Myung ;
  • James, Tony D. ;
  • Lewis, Simon E.

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dc.contributor.authorMurfin, Lloyd C.-
dc.contributor.authorWeber, Maria-
dc.contributor.authorPark, Sang Jun-
dc.contributor.authorKim, Won Tae-
dc.contributor.authorLopez-Alled, Carlos M.-
dc.contributor.authorMcMullin, Claire L.-
dc.contributor.authorPradaux-Caggiano, Fabienne-
dc.contributor.authorLyall, Catherine L.-
dc.contributor.authorKociok-Köhn, Gabriele-
dc.contributor.authorWenk, Jannis-
dc.contributor.authorBull, Steven D.-
dc.contributor.authorYoon, Juyoung-
dc.contributor.authorKim, Hwan Myung-
dc.contributor.authorJames, Tony D.-
dc.contributor.authorLewis, Simon E.-
dc.date.issued2019-12-11-
dc.identifier.urihttps://dspace.ajou.ac.kr/dev/handle/2018.oak/31050-
dc.description.abstractTwo-photon fluorescence microscopy has become an indispensable technique for cellular imaging. Whereas most two-photon fluorescent probes rely on well-known fluorophores, here we report a new fluorophore for bioimaging, namely azulene. A chemodosimeter, comprising a boronate ester receptor motif conjugated to an appropriately substituted azulene, is shown to be an effective two-photon fluorescent probe for reactive oxygen species, showing good cell penetration, high selectivity for peroxynitrite, no cytotoxicity, and excellent photostability.-
dc.description.sponsorshipWe are grateful for Ph.D. funding to C.M.L.-A. from the EU Horizon 2020 research and innovation program under Grant Agreement H2020-MSCA-CO-FUND, No. 665992. We thank the Center for Doctoral Training in Sustainable Chemical Technologies for Ph.D. funding to M.W. under EPSRC Grant EP/L016354/1. We also thank EPSRC for DTP Ph.D. funding to L.C.M. H.M.K. acknowledges a grant from the National Leading Research Lab Program of the National Research Foundation of Korea (NRF), funded by the Korean government (MSIP; No. 2016R1E1A1A02920873). In addition, T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and for funding to F.P.-C. under Grant CHGR1170010. This work was supported by a seed corn grant from the CR@B (Cancer Research at Bath) network. The British-Spanish Society and Plastic Energy are thanked for a 2017 Scholarship to C. M. L.-A. This research made use of the Balena High Performance Computing (HPC) Service at the University of Bath. NMR, X-ray crystallography, and MS facilities were provided through the Materials and Chemical Characterisation Facility (MC 2 ) at the University of Bath. We thank Prof. Uwe Pischel and Prof. Thorfinnur Gunnlaugsson for helpful discussions.-
dc.language.isoeng-
dc.publisherAmerican Chemical Society-
dc.subject.meshCell penetration-
dc.subject.meshCellular imaging-
dc.subject.meshFluorescent probes-
dc.subject.meshHigh selectivity-
dc.subject.meshReactive oxygen and nitrogen species-
dc.subject.meshReactive oxygen species-
dc.subject.meshTwo photon microscopy-
dc.subject.meshTwo-photon fluorescence microscopy-
dc.subject.meshAzulenes-
dc.subject.meshCell Survival-
dc.subject.meshFluorescent Dyes-
dc.subject.meshHeLa Cells-
dc.subject.meshHumans-
dc.subject.meshLimit of Detection-
dc.subject.meshMicroscopy, Fluorescence, Multiphoton-
dc.subject.meshReactive Nitrogen Species-
dc.subject.meshReactive Oxygen Species-
dc.titleAzulene-Derived Fluorescent Probe for Bioimaging: Detection of Reactive Oxygen and Nitrogen Species by Two-Photon Microscopy-
dc.typeArticle-
dc.citation.endPage19396-
dc.citation.startPage19389-
dc.citation.titleJournal of the American Chemical Society-
dc.citation.volume141-
dc.identifier.bibliographicCitationJournal of the American Chemical Society, Vol.141, pp.19389-19396-
dc.identifier.doi10.1021/jacs.9b09813-
dc.identifier.pmid31773957-
dc.identifier.scopusid2-s2.0-85076384021-
dc.identifier.urlhttp://pubs.acs.org/journal/jacsat-
dc.description.isoatrue-
dc.subject.subareaCatalysis-
dc.subject.subareaChemistry (all)-
dc.subject.subareaBiochemistry-
dc.subject.subareaColloid and Surface Chemistry-
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