Citation Export
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kim, Eun Sun | - |
| dc.contributor.author | Jang, Hongjun | - |
| dc.contributor.author | Chang, Sun Young | - |
| dc.contributor.author | Baek, Seung Hoon | - |
| dc.contributor.author | Bae, Ok Nam | - |
| dc.contributor.author | Kim, Hyoungsu | - |
| dc.date.issued | 2018-12-28 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/dev/handle/2018.oak/30515 | - |
| dc.description.abstract | A concise synthesis of sericetin (1) was performed in four steps from readily available 3-O-benzylgalangin (4), featuring electrocyclization to produce the tricyclic core and a sequential aromatic Claisen/Cope rearrangement to incorporate the 8-prenyl group of 1. In addition, the therapeutic potential of sericetin (1), isosericetin (2), and three prenylated tetracyclic synthetic intermediates (11, 12, and 14) against cisplatin-induced nephrotoxicity using renal tubular cells were evaluated. Compound 14 showed therapeutic potential against cisplatin-induced kidney damage. | - |
| dc.description.sponsorship | We thank Professor S. Ruchirawat (Chulabhorn Graduate Institute) for providing the spectra of sericetin. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (NRF-2017R1A2B4004155 and NRF-2017R1C1B3002626). | - |
| dc.language.iso | eng | - |
| dc.publisher | American Chemical Society | - |
| dc.subject.mesh | Acute Kidney Injury | - |
| dc.subject.mesh | Animals | - |
| dc.subject.mesh | Cell Line | - |
| dc.subject.mesh | Cisplatin | - |
| dc.subject.mesh | Fabaceae | - |
| dc.subject.mesh | Molecular Structure | - |
| dc.subject.mesh | Protective Agents | - |
| dc.subject.mesh | Rats | - |
| dc.subject.mesh | Rats, Sprague-Dawley | - |
| dc.title | Total Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury | - |
| dc.type | Article | - |
| dc.citation.endPage | 2653 | - |
| dc.citation.startPage | 2647 | - |
| dc.citation.title | Journal of Natural Products | - |
| dc.citation.volume | 81 | - |
| dc.identifier.bibliographicCitation | Journal of Natural Products, Vol.81, pp.2647-2653 | - |
| dc.identifier.doi | 10.1021/acs.jnatprod.8b00434 | - |
| dc.identifier.pmid | 30540183 | - |
| dc.identifier.scopusid | 2-s2.0-85058642830 | - |
| dc.identifier.url | http://pubs.acs.org/journal/jnprdf | - |
| dc.description.isoa | false | - |
| dc.subject.subarea | Analytical Chemistry | - |
| dc.subject.subarea | Molecular Medicine | - |
| dc.subject.subarea | Pharmacology | - |
| dc.subject.subarea | Pharmaceutical Science | - |
| dc.subject.subarea | Drug Discovery | - |
| dc.subject.subarea | Complementary and Alternative Medicine | - |
| dc.subject.subarea | Organic Chemistry | - |
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