Citation Export
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Pak, Yen Leng | - |
| dc.contributor.author | Park, Sang Jun | - |
| dc.contributor.author | Song, Gyeongok | - |
| dc.contributor.author | Yim, Yubin | - |
| dc.contributor.author | Kang, Hyuk | - |
| dc.contributor.author | Kim, Hwan Myung | - |
| dc.contributor.author | Bouffard, Jean | - |
| dc.contributor.author | Yoon, Juyoung | - |
| dc.date.issued | 2018-11-06 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/dev/handle/2018.oak/30440 | - |
| dc.description.abstract | The naphthoimidazolium borane 4 is shown to be a selective probe for HOCl over other reactive oxygen species. Unlike other boronate-reactive oxygen species (ROS) fluorogenic probes that are oxidized by HOCl through a nucleophilic borono-Dakin oxidation mechanism, probe 4 is distinguished by its electrophilic oxidation mechanism involving B-H bond cleavage. Two-photon microscopy experiments in living cells and tissues with the probe 4 demonstrate the monitoring of endogenous HOCl generation and changes in HOCl concentrations generated in the endoplasmic reticulum during oxidative stress situations. | - |
| dc.description.sponsorship | We thank the National Research Foundation of Korea for the financial support (2012R1A3A2048814 to J.Y., 2016-R1E1A1A02920873 to H.M.K., and 2018R1D1A1B07043568 to J.B.). We also thank the Western Seoul (LC\u2212MS) and Daegu (FAB) branches of the Korea Basic Science Institute for mass spectrometric data. | - |
| dc.language.iso | eng | - |
| dc.publisher | American Chemical Society | - |
| dc.subject.mesh | Electrophilic oxidation | - |
| dc.subject.mesh | Endoplasmic reticulum | - |
| dc.subject.mesh | Fluorogenic probes | - |
| dc.subject.mesh | Microscopic imaging | - |
| dc.subject.mesh | N-heterocyclic carbenes | - |
| dc.subject.mesh | Oxidation mechanisms | - |
| dc.subject.mesh | Reactive oxygen species | - |
| dc.subject.mesh | Two photon microscopy | - |
| dc.subject.mesh | Animals | - |
| dc.subject.mesh | Boranes | - |
| dc.subject.mesh | Cell Line, Tumor | - |
| dc.subject.mesh | Endoplasmic Reticulum | - |
| dc.subject.mesh | Fluorescent Dyes | - |
| dc.subject.mesh | Humans | - |
| dc.subject.mesh | Hydrolysis | - |
| dc.subject.mesh | Hypochlorous Acid | - |
| dc.subject.mesh | Imidazoles | - |
| dc.subject.mesh | Male | - |
| dc.subject.mesh | Mice | - |
| dc.subject.mesh | Microscopy | - |
| dc.subject.mesh | Oxidation-Reduction | - |
| dc.subject.mesh | Rats, Sprague-Dawley | - |
| dc.subject.mesh | RAW 264.7 Cells | - |
| dc.subject.mesh | Ultraviolet Rays | - |
| dc.title | Endoplasmic Reticulum-Targeted Ratiometric N-Heterocyclic Carbene Borane Probe for Two-Photon Microscopic Imaging of Hypochlorous Acid | - |
| dc.type | Article | - |
| dc.citation.endPage | 12943 | - |
| dc.citation.startPage | 12937 | - |
| dc.citation.title | Analytical Chemistry | - |
| dc.citation.volume | 90 | - |
| dc.identifier.bibliographicCitation | Analytical Chemistry, Vol.90, pp.12937-12943 | - |
| dc.identifier.doi | 10.1021/acs.analchem.8b03565 | - |
| dc.identifier.pmid | 30303000 | - |
| dc.identifier.scopusid | 2-s2.0-85055715299 | - |
| dc.identifier.url | http://pubs.acs.org/journal/ancham | - |
| dc.description.isoa | false | - |
| dc.subject.subarea | Analytical Chemistry | - |
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