This study was supported by grants from the Ministry of Health and Welfare (HI14C2180) and from the National Research Foundation (NRF-2017R1C1B3002626) of Korea. This article was partially prepared at the National Institute for Health Research (NIHR) Sheffield Biomedical Research Centre (Translational Neuroscience). The views expressed are those of the author(s) and not necessarily those of the NIHR.