We aimed to evaluate the prognostic performance of bilateral ASPECTS (ASPECTS-b) to predict neurologic outcome in post cardiac arrest patients treated with targeted temperature management (TTM). We conducted a retrospective study of post cardiac arrest patients treated with TTM in two tertiary hospitals. The ASPECTS-b and GWR on brain computed tomography (CT) achieved within 6 hours of return of spontaneous resuscitation (ROSC) was measured twice from each institute. ROC curve analysis of ASPECTS-b and comparison of the ROC curve from each institute was done to assess the performance in predicting poor neurologic outcome (CPC 3-5). A total of 66 patients from institute A and 109 patients from institute B was studied. Of the total of 175 patients enrolled, 117 patients (66.9%) had poor neurologic outcome. ASPECTS-b showed good prognostic performance to predict poor neurologic outcome [AUROC 0.72 (0.64-0.80)] and was not significantly different between institutes [institute A vs. institute B, AUROC 0.83 (95%CI 0.72-0.94) vs. AUROC 0.73(95%CI 0.64-0.83), p=0.2]. ASPECTS-b measured from initial brain CT not only expressed good performance in predicting poor neurologic outcomes in post cardiac arrest patients, but showed similar performances between two different institutes.
