The thioamides functional group has been commonly found its
application in biochemistry like antithyroid drugs. It is also used in
industrial application as vulcanization agents and grease additives.
Previous reported methods for the synthesis of thioamides involved the
use of excess amount of sulfur transfer agent which is desirable from the
environmental point of view. Herein, we proposed a method for the
synthesis of thioamides using a copper catalyzed aerobic oxidation of
thiols. This protocol seems to be more step-economic and atomeconomic
as it avoids the use of exogenous sulfur reagent.
